PMID- 26486745
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20151021
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 144
IP  - 5
DP  - 2015 Nov
TI  - Thyroid-like follicular carcinoma of the kidney: one case report and review of 
      the literature.
PG  - 796-804
LID - 10.1309/AJCP6P0STAAHOTTG [doi]
AB  - OBJECTIVES: Thyroid-like follicular carcinoma of the kidney continues to confound 
      the practicing pathologist with its close resemblance to the follicular variant 
      of thyroid carcinoma, as well as other benign and malignant entities. Our goal is 
      to expand the knowledge of this rare renal cell carcinoma subtype, which is 
      morphologically similar to follicular carcinoma of the thyroid but lacks 
      expression of characteristic thyroid immunohistochemical markers such as TTF-1 
      and thyroglobulin. METHODS: We evaluated the gross, histologic, 
      immunohistochemical, and fluorescence in situ hybridization (FISH) studies of a 
      new case and performed a comprehensive review of the literature. RESULTS: The 
      lesion was spongy and well-circumscribed. Microscopically it showed variably 
      sized follicular structures, filled with abundant, deeply eosinophilic, 
      colloid-like material. At the periphery, it displayed areas resembling 
      metanephric adenoma and early stages of nephrogenesis. The tumor cells strongly 
      expressed CK7, PAX-8, PAX-2, vimentin, EMA, and CK19 immunostains. Other markers, 
      such as CD10, RCC, HBME-1, thyroglobulin, and TTF-1, were not immunoreactive. The 
      tumor was negative for trisomy of both 7 and 17 and showed borderline monosomies 
      (losses) of both chromosomes in FISH studies. CONCLUSIONS: Five years of 
      preoperative observation and lack of recurrence bring further insight into the 
      slow progressive nature of this neoplasm and support a low malignant potential. 
      Proper identification is important to secure adequate treatment and follow-up.
CI  - Copyright(c) by the American Society for Clinical Pathology.
FAU - Dawane, Rahul
AU  - Dawane R
AD  - From the Department of Pathology and.
FAU - Grindstaff, Alan
AU  - Grindstaff A
AD  - From the Department of Pathology and.
FAU - Parwani, Anil V
AU  - Parwani AV
AD  - Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
FAU - Brock, Timothy
AU  - Brock T
AD  - Division of Urologic Surgery, University of Tennessee Medical Center, Knoxville 
      and.
FAU - White, Wesley M
AU  - White WM
AD  - Division of Urologic Surgery, University of Tennessee Medical Center, Knoxville 
      and.
FAU - Nodit, Laurentia
AU  - Nodit L
AD  - From the Department of Pathology and Lnodit@utmck.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adenocarcinoma, Follicular/metabolism/*pathology
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Renal Cell/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney/metabolism/*pathology
MH  - Kidney Neoplasms/metabolism/*pathology
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*pathology
OTO - NOTNLM
OT  - Kidney tumor
OT  - Renal cell carcinoma
OT  - Thyroid-like follicular carcinoma of kidney
EDAT- 2015/10/22 06:00
MHDA- 2016/02/03 06:00
CRDT- 2015/10/22 06:00
PHST- 2015/10/22 06:00 [entrez]
PHST- 2015/10/22 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
AID - 144/5/796 [pii]
AID - 10.1309/AJCP6P0STAAHOTTG [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2015 Nov;144(5):796-804. doi: 10.1309/AJCP6P0STAAHOTTG.