PMID- 26486746
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20161125
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 144
IP  - 5
DP  - 2015 Nov
TI  - Primary cutaneous follicle center lymphoma associated with an extracutaneous 
      dissemination: a cytogenetic finding of potential prognostic value.
PG  - 805-10
LID - 10.1309/AJCPV3F9BEFCTAOQ [doi]
AB  - OBJECTIVES: Cytogenetic studies on cutaneous lymphomas are rare, and very little 
      is known about their prognostic value. We present a rare case of primary 
      cutaneous follicle center lymphoma (PCFCL) with a complex translocation 
      presenting with cutaneous and extracutaneous dissemination in the lymph node. 
      METHODS: Morphologic, immunohistochemical, conventional cytogenetic, and 
      fluorescence in situ hybridization (FISH) studies were performed on this patient. 
      RESULTS: A combination of cytogenetic and FISH analysis identified a complex 
      novel four-way t(2;14;9;3) (p11.2;q32;p13;q27) translocation involving 
      rearrangements of BCL6, immunoglobulin light and heavy chain genes, and an 
      unknown gene on 9p. CONCLUSIONS: Our report elaborates the morphologic and 
      immunohistochemical features in combination with cytogenetic and molecular 
      cytogenetic analysis of PCFCL, which provide additional insight into the clinical 
      and biologic behavior of this lesion.
CI  - Copyright(c) by the American Society for Clinical Pathology.
FAU - Subramaniyam, Shivakumar
AU  - Subramaniyam S
AD  - From the Department of Pathology and Laboratory Medicine, Weill Cornell Medical 
      College, New York Presbyterian Hospital, New York, NY. 
      ssubramaniyam@winthrop.org.
FAU - Magro, Cynthia M
AU  - Magro CM
AD  - From the Department of Pathology and Laboratory Medicine, Weill Cornell Medical 
      College, New York Presbyterian Hospital, New York, NY.
FAU - Gogineni, Swarna
AU  - Gogineni S
AD  - From the Department of Pathology and Laboratory Medicine, Weill Cornell Medical 
      College, New York Presbyterian Hospital, New York, NY.
FAU - Tam, Wayne
AU  - Tam W
AD  - From the Department of Pathology and Laboratory Medicine, Weill Cornell Medical 
      College, New York Presbyterian Hospital, New York, NY.
FAU - Mathew, Susan
AU  - Mathew S
AD  - From the Department of Pathology and Laboratory Medicine, Weill Cornell Medical 
      College, New York Presbyterian Hospital, New York, NY.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (BCL6 protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Immunoglobulin Light Chains)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
SB  - IM
MH  - Cytogenetics
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Immunoglobulin Light Chains/genetics
MH  - Lymphoma, Follicular/*genetics/pathology
MH  - Middle Aged
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Skin/*pathology
MH  - Skin Neoplasms/*genetics/pathology
MH  - *Translocation, Genetic
OTO - NOTNLM
OT  - Complex translocation
OT  - Extracutaneous dissemination
OT  - Primary cutaneous follicle center lymphoma
OT  - Prognosis
EDAT- 2015/10/22 06:00
MHDA- 2016/02/03 06:00
CRDT- 2015/10/22 06:00
PHST- 2015/10/22 06:00 [entrez]
PHST- 2015/10/22 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
AID - 144/5/805 [pii]
AID - 10.1309/AJCPV3F9BEFCTAOQ [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2015 Nov;144(5):805-10. doi: 10.1309/AJCPV3F9BEFCTAOQ.