PMID- 26488310
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20170110
IS  - 1541-2563 (Electronic)
IS  - 1541-2563 (Linking)
VI  - 13
IP  - 2
DP  - 2016
TI  - COPD Patients Have Short Lung Magnetic Resonance T1 Relaxation Time.
PG  - 153-9
LID - 10.3109/15412555.2015.1048851 [doi]
AB  - Magnetic resonance imaging (MRI) may provide attractive biomarkers for assessment 
      of pulmonary disease in clinical trials as it is free from ionizing radiation, 
      minimally invasive and allows regional information. The aim of this study was to 
      characterize lung MRI T1 relaxation time as a biomarker of chronic obstructive 
      pulmonary disease (COPD); and specifically its relationship to smoking history, 
      computed tomography (CT), and pulmonary function test (PFT) measurements in 
      comparison to healthy age-matched controls. Lung T1 and inter-quartile range 
      (IQR) of T1 maps from 24 COPD subjects and 12 healthy age-matched non-smokers 
      were retrospectively analyzed from an institutional review board approved study. 
      The subjects underwent PFTs and two separate MR imaging sessions at 1.5 tesla to 
      test T1 repeatability. CT scans were performed on the COPD subjects. T1 
      repeatability (intraclass correlation coefficient) was 0.72 for repeated scans 
      acquired on two visits. The lung T1 was significantly shorter (p < 0.0001) and T1 
      IQR was significantly larger (p = 0.0002) for the COPD subjects compared to 
      healthy controls. Lung T1 significantly (p = 0.001) correlated with lung density 
      assessed with CT. Strong significant correlations (p < 0.0001) between lung T1 
      and all PFT measurements were observed. Cigarette exposure did not correlate with 
      lung T1 in COPD subjects. In conclusion, lung MRI T1 mapping shows potential as a 
      repeatable, radiation free, non-invasive imaging technique in the evaluation of 
      COPD.
FAU - Alamidi, Daniel F
AU  - Alamidi DF
AD  - a 1 Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska 
      Academy, University of Gothenburg , Gothenburg , Sweden.
FAU - Morgan, Alexandra R
AU  - Morgan AR
AD  - b 2 Bioxydyn Ltd , Manchester , United Kingdom.
AD  - c 3 Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester 
      Academic Health Sciences Centre, University of Manchester , Manchester , United 
      Kingdom.
FAU - Hubbard Cristinacce, Penny L
AU  - Hubbard Cristinacce PL
AD  - c 3 Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester 
      Academic Health Sciences Centre, University of Manchester , Manchester , United 
      Kingdom.
FAU - Nordenmark, Lars H
AU  - Nordenmark LH
AD  - d 4 AstraZeneca R&D , Molndal , Sweden.
FAU - Hockings, Paul D
AU  - Hockings PD
AD  - e 5 Antaros Medical, BioVenture Hub , Molndal , Sweden.
AD  - f 6 Medtech West, Chalmers University of Technology , Gothenburg , Sweden.
FAU - Lagerstrand, Kerstin M
AU  - Lagerstrand KM
AD  - a 1 Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska 
      Academy, University of Gothenburg , Gothenburg , Sweden.
FAU - Young, Simon S
AU  - Young SS
AD  - g 7 AstraZeneca R&D , Alderley Park, United Kingdom.
FAU - Naish, Josephine H
AU  - Naish JH
AD  - c 3 Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester 
      Academic Health Sciences Centre, University of Manchester , Manchester , United 
      Kingdom.
FAU - Waterton, John C
AU  - Waterton JC
AD  - c 3 Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester 
      Academic Health Sciences Centre, University of Manchester , Manchester , United 
      Kingdom.
FAU - Maguire, Niall C
AU  - Maguire NC
AD  - b 2 Bioxydyn Ltd , Manchester , United Kingdom.
FAU - Olsson, Lars E
AU  - Olsson LE
AD  - h 8 Department of Medical Radiation Physics, Translational Medicine, Lund 
      University , Malmo , Sweden.
FAU - Parker, Geoffrey J M
AU  - Parker GJ
AD  - b 2 Bioxydyn Ltd , Manchester , United Kingdom.
AD  - c 3 Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester 
      Academic Health Sciences Centre, University of Manchester , Manchester , United 
      Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151021
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Lung/*diagnostic imaging/physiopathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*diagnosis/physiopathology
MH  - Respiratory Function Tests
MH  - Retrospective Studies
MH  - Smoking/adverse effects
MH  - Tomography, X-Ray Computed/methods
OTO - NOTNLM
OT  - biomarker
OT  - chronic obstructive pulmonary disease (COPD)
OT  - longitudinal relaxation time
OT  - lung imaging
OT  - magnetic resonance imaging (MRI)
OT  - smoking
EDAT- 2015/10/22 06:00
MHDA- 2017/01/10 06:00
CRDT- 2015/10/22 06:00
PHST- 2015/10/22 06:00 [entrez]
PHST- 2015/10/22 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
AID - 10.3109/15412555.2015.1048851 [doi]
PST - ppublish
SO  - COPD. 2016;13(2):153-9. doi: 10.3109/15412555.2015.1048851. Epub 2015 Oct 21.