PMID- 26488448
OWN - NLM
STAT- MEDLINE
DCOM- 20160913
LR  - 20220310
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 20
IP  - 6-7
DP  - 2015
TI  - Diagnostic utility of BNP, corin and furin as biomarkers for cardiovascular 
      complications in type 2 diabetes mellitus patients.
PG  - 460-9
LID - 10.3109/1354750X.2015.1093032 [doi]
AB  - CONTEXT: The number of patients with type 2 diabetes mellitus (T2DM) is 
      progressively increasing, and diabetic cardiovascular complications have become a 
      public health problem. Brain or B-type natriuretic peptide (BNP) is a cardiac 
      hormone synthesized as a pre-pro-peptide. pro-BNP is produced by cleaving the 
      signal peptide then two proprotein convertases, corin and furin cleave pro-BNP to 
      form a biologically active hormone. Two corin single nucleotide polymorphisms 
      (SNPs) have been reported to alter corin protein conformation and impair its 
      biological activity. OBJECTIVE: We aimed to investigate the potential role of 
      corin and furin in comparison to BNP as biomarkers for predicting cardiovascular 
      complications in T2DM patients. The association of corin gene SNPs with corin 
      levels was also examined. METHODS: Seventy-five subjects were recruited in this 
      study, including 25 T2DM patients with complications, 25 T2DM patients without 
      complications as well as 25 healthy subjects. Plasma BNP, corin and furin levels 
      were measured using enzyme-linked immunosorbent assays. Two corin SNPs were 
      genotyped using allele specific oligonucleotide-polymerase chain reaction. 
      RESULTS: Both furin and BNP were found to be more sensitive than corin (80% 
      versus 56%, p = 0.008), whereas furin showed higher specificity when compared to 
      BNP (96% versus 84%, p = 0.041) and corin (96% versus 64%, p < 0.0001) in 
      predicting cardiovascular complications in T2DM patients. Corin SNPs are not 
      associated with corin levels, neither in the entire study cohort nor in the 
      subgroup of T2DM patients with cardiovascular complications (p > 0.05). 
      CONCLUSIONS: Furin may be useful, either alone or in combination with other 
      biomarkers, for cardiovascular risk stratification assessment in T2DM patients.
FAU - Fathy, Shadia A
AU  - Fathy SA
AD  - a Department of Biochemistry , Faculty of Science, Ain Shams University , Cairo , 
      Egypt .
FAU - Abdel Hamid, Fatma F
AU  - Abdel Hamid FF
AD  - a Department of Biochemistry , Faculty of Science, Ain Shams University , Cairo , 
      Egypt .
FAU - Zabut, Baker M
AU  - Zabut BM
AD  - b Biochemistry Department , Faculty of Science, Islamic University , Gaza , 
      Palestine .
FAU - Jamee, Amal F
AU  - Jamee AF
AD  - c Cardiology Department , El-Shifa Hospital , Gaza , Palestine , and.
FAU - Ali, Mohamed A M
AU  - Ali MA
AD  - a Department of Biochemistry , Faculty of Science, Ain Shams University , Cairo , 
      Egypt .
FAU - Abu Mustafa, Ayman M
AU  - Abu Mustafa AM
AD  - d General Directorate of Human Resources Development, Ministry of Health , Gaza , 
      Palestine.
LA  - eng
PT  - Journal Article
DEP - 20151021
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - EC 3.4.21.- (CORIN protein, human)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - EC 3.4.21.75 (Furin)
SB  - IM
MH  - Aged
MH  - Biomarkers/*blood
MH  - Cardiovascular Diseases/*blood/complications/diagnosis
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications/genetics
MH  - Female
MH  - Furin/*blood
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - ROC Curve
MH  - Serine Endopeptidases/*blood/genetics
OTO - NOTNLM
OT  - BNP
OT  - cardiovascular complications
OT  - corin
OT  - furin
OT  - type 2 diabetes mellitus
EDAT- 2015/10/22 06:00
MHDA- 2016/09/14 06:00
CRDT- 2015/10/22 06:00
PHST- 2015/10/22 06:00 [entrez]
PHST- 2015/10/22 06:00 [pubmed]
PHST- 2016/09/14 06:00 [medline]
AID - 10.3109/1354750X.2015.1093032 [doi]
PST - ppublish
SO  - Biomarkers. 2015;20(6-7):460-9. doi: 10.3109/1354750X.2015.1093032. Epub 2015 Oct 
      21.