PMID- 26489585
OWN - NLM
STAT- MEDLINE
DCOM- 20160104
LR  - 20161125
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 42
IP  - 10
DP  - 2015 Oct
TI  - [Everolimus plus Exemestane in Postmenopausal Metastatic Breast Cancer Patients].
PG  - 1319-21
AB  - The purpose of our study was to test the efficacy and toxicity of everolimus plus 
      exemestane therapy for breast cancer. Between 2014 and 2015, 20 patients 
      diagnosed with breast carcinoma were selected for this retrospective study. 
      Patients received everolimus plus exemestane. As a result, 4 patients showed a 
      partial response to treatment and the median PFS was 2.5 months (range, 1-9). The 
      most common adverse events (AEs) associated with combination therapy were 
      stomatitis, rash, dysgeusia, and non-infectious lung disease. The AEs reported 
      were mostly grade 1 and 2, and manageable with appropriate intervention. 
      Therefore, everolimus plus exemestane therapy for breast cancer seems to be 
      effective and generally tolerable.
FAU - Yamamoto, Daigo
AU  - Yamamoto D
AD  - Dept. of Surgery, Kansai Medical University.
FAU - Tsubota, Yu
AU  - Tsubota Y
FAU - Sueoka, Noriko
AU  - Sueoka N
FAU - Yamamoto, Chizuko
AU  - Yamamoto C
FAU - Kon, Masanori
AU  - Kon M
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Androstadienes)
RN  - 9HW64Q8G6G (Everolimus)
RN  - NY22HMQ4BX (exemestane)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Androstadienes/administration & dosage/adverse effects
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
MH  - Breast Neoplasms/*drug therapy/pathology/surgery
MH  - Everolimus/administration & dosage/adverse effects
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Postmenopause
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2015/10/23 06:00
MHDA- 2016/01/05 06:00
CRDT- 2015/10/23 06:00
PHST- 2015/10/23 06:00 [entrez]
PHST- 2015/10/23 06:00 [pubmed]
PHST- 2016/01/05 06:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2015 Oct;42(10):1319-21.