PMID- 2648967
OWN - NLM
STAT- MEDLINE
DCOM- 19890427
LR  - 20131121
IS  - 0003-3928 (Print)
IS  - 0003-3928 (Linking)
VI  - 38
IP  - 1
DP  - 1989 Jan
TI  - [Cardiac arrhythmia in moderate arterial hypertension. Epidemiologic survey of 
      251 cases. Effect of sotalol].
PG  - 47-51
AB  - 251 untreated patients with mild to moderate hypertension were included in a 
      multicenter study aimed 1) to detect arrhythmias (24-H Holter recording) and 2) 
      to assess the efficacy of sotalol on blood pressure and possible arrhythmias. 
      Patients with coronary heart disease or previously documented arrhythmias were 
      excluded. Atrial arrhythmias such as premature beats, fibrillation, flutter and 
      paroxysmal atrial tachycardia were detected in 16% of patients. Monomorphic 
      ventricular premature contractions (VPCs) (Lown I and II) were detected in 41% of 
      patients and polymorphic VPCs or duplets/triplets (Lown III and IV) in 14%. A 
      correlation seems to exist between the level of hypertensive cardiopathy, judged 
      on electrocardiographic data (Tarazi classification), age of patients and 
      severity of arrhythmias. Sotalol was administered during 2 months at a mean dose 
      of 160 mg per day. The treatment was effective on blood pressure and arrhythmias 
      (82% improvement of severe VPCs) and the drug was well tolerated. It was 
      difficult to conclude if these good results are due to the betablocking 
      properties or specific class II antiarrhythmic effects of sotalol or to the 
      combined activity.
FAU - Clementy, J
AU  - Clementy J
AD  - Hopital Cardiologique du Haut-Leveque, Bordeaux Pessac.
FAU - Safar, M
AU  - Safar M
FAU - Vrancea, F
AU  - Vrancea F
LA  - fre
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
TT  - Les troubles du rythme cardiaque dans l'hypertension arterielle moderee. Enquete 
      epidemiologique sur 251 cas. Effet du sotalol.
PL  - France
TA  - Ann Cardiol Angeiol (Paris)
JT  - Annales de cardiologie et d'angeiologie
JID - 0142167
RN  - A6D97U294I (Sotalol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arrhythmias, Cardiac/drug therapy/*etiology
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Hypertension/*complications/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Multicenter Studies as Topic
MH  - Sotalol/*therapeutic use
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Cardiol Angeiol (Paris). 1989 Jan;38(1):47-51.