PMID- 26489733
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20181113
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Print)
IS  - 0168-3659 (Linking)
VI  - 219
DP  - 2015 Dec 10
TI  - Engineering immunity: Modulating dendritic cell subsets and lymph node response 
      to direct immune-polarization and vaccine efficacy.
PG  - 610-621
LID - S0168-3659(15)30163-2 [pii]
LID - 10.1016/j.jconrel.2015.09.063 [doi]
AB  - While successful vaccines have been developed against many pathogens, there are 
      still many diseases and pathogenic infections that are highly evasive to current 
      vaccination strategies. Thus, more sophisticated approaches to control the type 
      and quality of vaccine-induced immune response must be developed. Dendritic cells 
      (DCs) are the sentinels of the body and play a critical role in immune response 
      generation and direction by bridging innate and adaptive immunity. It is now well 
      recognized that DCs can be separated into many subgroups, each of which has a 
      unique function. Better understanding of how various DC subsets, in lymphoid 
      organs and in the periphery, can be targeted through controlled delivery; and how 
      these subsets modulate and control the resulting immune response could greatly 
      enhance our ability to develop new, effective vaccines against complex diseases. 
      In this review, we provide an overview of DC subset biology and discuss current 
      immunotherapeutic strategies that utilize DC targeting to modulate and control 
      immune responses.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Leleux, Jardin
AU  - Leleux J
AD  - The Wallace H. Coulter Dept. of Biomedical Engineering at Georgia Tech and Emory 
      University and The Center for Immunoengineering at Georgia Tech, The Parker H. 
      Petit Institute for Bioengineering and Biosciences Georgia Institute of 
      Technology, Atlanta, GA 30332, United States.
FAU - Atalis, Alexandra
AU  - Atalis A
AD  - The Wallace H. Coulter Dept. of Biomedical Engineering at Georgia Tech and Emory 
      University and The Center for Immunoengineering at Georgia Tech, The Parker H. 
      Petit Institute for Bioengineering and Biosciences Georgia Institute of 
      Technology, Atlanta, GA 30332, United States.
FAU - Roy, Krishnendu
AU  - Roy K
AD  - The Wallace H. Coulter Dept. of Biomedical Engineering at Georgia Tech and Emory 
      University and The Center for Immunoengineering at Georgia Tech, The Parker H. 
      Petit Institute for Bioengineering and Biosciences Georgia Institute of 
      Technology, Atlanta, GA 30332, United States. Electronic address: 
      krish.roy@gatech.edu.
LA  - eng
GR  - T32 GM008433/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20151020
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Lymph Nodes/immunology
MH  - Macrophages/immunology
MH  - Molecular Targeted Therapy
MH  - Vaccines/*immunology
PMC - PMC5669361
MID - NIHMS914812
OTO - NOTNLM
OT  - DC subsets
OT  - Dendritic cells
OT  - Drug delivery
OT  - Immunomodulation
OT  - Immunotherapy
OT  - Lymph node
OT  - Vaccines
EDAT- 2015/10/23 06:00
MHDA- 2016/09/13 06:00
PMCR- 2017/11/03
CRDT- 2015/10/23 06:00
PHST- 2015/07/02 00:00 [received]
PHST- 2015/09/25 00:00 [revised]
PHST- 2015/09/28 00:00 [accepted]
PHST- 2015/10/23 06:00 [entrez]
PHST- 2015/10/23 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
PHST- 2017/11/03 00:00 [pmc-release]
AID - S0168-3659(15)30163-2 [pii]
AID - 10.1016/j.jconrel.2015.09.063 [doi]
PST - ppublish
SO  - J Control Release. 2015 Dec 10;219:610-621. doi: 10.1016/j.jconrel.2015.09.063. 
      Epub 2015 Oct 20.