PMID- 26489977
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20180318
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 10
IP  - 4
DP  - 2016 Dec
TI  - Disrupted default mode network connectivity in male adolescents with conduct 
      disorder.
PG  - 995-1003
AB  - Conduct disorder (CD) is a serious behavioral disorder of childhood and 
      adolescence. The default mode network (DMN) is a brain network which supports 
      self-referential cognitive processes and is typically deactivated during task 
      performance. The aim of this study was to investigate DMN connectivity in male 
      adolescents with pure CD compared to typically-developing controls. Eighteen male 
      adolescents with CD and 18 sex-, age- and education-matched typically-developing 
      (TD) participants were recruited. Current and lifetime psychiatric disorders were 
      assessed using the Chinese version of the Schedule for Affective Disorder and 
      Schizophrenia for School-Age Children-Present and Lifetime Version. Resting state 
      functional magnetic resonance imaging (fMRI) data were obtained using a 3.0 T 
      scanner. Independent components analysis (ICA) was used to investigate functional 
      connectivity between the DMN and related brain regions. DMN activity was observed 
      in medial prefrontal, posterior cingulate, and lateral parietal cortices, and 
      extended to the brainstem. Adolescents with CD showed significantly reduced 
      functional connectivity within the bilateral posterior cingulate cortex (PCC), 
      bilateral precuneus and right superior temporal gyrus relative to TD controls. CD 
      is associated with reduced functional connectivity within the DMN and between the 
      DMN and other regions. These preliminary results suggest that deficits in DMN 
      functional connectivity may serve as a biomarker of CD.
FAU - Zhou, Jiansong
AU  - Zhou J
AD  - Mental Health Institute of The Second Xiangya Hospital, Hunan Province Technology 
      Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan 
      Province, Central South University, Changsha, 410011, China. 
      zhoujs2003@aliyun.com.
FAU - Yao, Nailin
AU  - Yao N
AD  - Department of Psychiatry, Yale University & Olin Neuropsychiatric Research 
      Center, Institute of Living, Whitehall Research, Building 200, Retreat Ave, 
      Hartford, CT, 06106, USA.
FAU - Fairchild, Graeme
AU  - Fairchild G
AD  - Academic Unit of Psychology, University of Southampton, Southampton, UK.
FAU - Cao, Xia
AU  - Cao X
AD  - Department of Health Management Center, The Third Xiangya Hospital, Central South 
      University, China Tongzipo Road 138, Changsha, 410013, Hunan Province, China.
FAU - Zhang, Yingdong
AU  - Zhang Y
AD  - Mental Health Institute of The Second Xiangya Hospital, Hunan Province Technology 
      Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan 
      Province, Central South University, Changsha, 410011, China.
FAU - Xiang, Yu-Tao
AU  - Xiang YT
AD  - Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao, SAR, 
      China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Mental Health Institute of The Second Xiangya Hospital, Hunan Province Technology 
      Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan 
      Province, Central South University, Changsha, 410011, China.
FAU - Wang, Xiaoping
AU  - Wang X
AD  - Mental Health Institute of The Second Xiangya Hospital, Hunan Province Technology 
      Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan 
      Province, Central South University, Changsha, 410011, China. xyjw6@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Adolescent
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Brain Mapping
MH  - Conduct Disorder/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Rest
OTO - NOTNLM
OT  - Adolescence
OT  - Conduct disorder
OT  - Default-mode network
OT  - Functional magnetic resonance imaging (fMRI)
OT  - Resting state
EDAT- 2015/10/23 06:00
MHDA- 2017/10/17 06:00
CRDT- 2015/10/23 06:00
PHST- 2015/10/23 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2015/10/23 06:00 [entrez]
AID - 10.1007/s11682-015-9465-6 [pii]
AID - 10.1007/s11682-015-9465-6 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2016 Dec;10(4):995-1003. doi: 10.1007/s11682-015-9465-6.