PMID- 26490062
OWN - NLM
STAT- MEDLINE
DCOM- 20160210
LR  - 20181202
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 67
IP  - 5
DP  - 2015 Oct 25
TI  - Brain-derived neurotrophic factor in the anterior cingulate cortex is involved in 
      the formation of fear memory.
PG  - 455-62
AB  - Brain-derived neurotrophic factor (BDNF), a small dimeric secretory protein, 
      plays a vital role in activity-dependent synaptic plasticity, learning and 
      memory. It has been shown that BDNF in the hippocampus and amygdala participates 
      in the formation of fear memory. However, little is known about the functional 
      role of BDNF in the anterior cingulate cortex (ACC). To address this question, we 
      examined the mRNA and protein levels of BDNF in the ACC of rats at various time 
      points after fear conditioning, using quantitative real-time PCR and 
      enzyme-linked immunosorbent assay (ELISA). The results showed that BDNF exhibited 
      a temporally specific increase in both mRNA and protein levels after CS (tone) 
      and US (foot shock) was paired. Such increase did not occur after the animals 
      were exposed to CS or US alone. When BDNF antibody was locally infused into the 
      ACC prior to CS-US pairing, both contextual and auditory fear memories were 
      severely impaired. Taken together, these results suggest that BDNF in the ACC is 
      required for the formation of fear memory.
FAU - Li, Qing-Qing
AU  - Li QQ
AD  - Institute of Neurobiology, State Key Laboratory of Medical Neurobiology, and 
      Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
FAU - Li, Bao-Ming
AU  - Li BM
AD  - Institute of Neurobiology, State Key Laboratory of Medical Neurobiology, and 
      Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
AD  - Center for Neuropsychiatric Disorders, Institute of Life Science, Nanchang 
      University, Nanchang 330031, China. bmli@ncu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *Fear
MH  - Gyrus Cinguli/*metabolism
MH  - Memory/*physiology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Real-Time Polymerase Chain Reaction
EDAT- 2015/10/23 06:00
MHDA- 2016/02/11 06:00
CRDT- 2015/10/23 06:00
PHST- 2015/10/23 06:00 [entrez]
PHST- 2015/10/23 06:00 [pubmed]
PHST- 2016/02/11 06:00 [medline]
PST - ppublish
SO  - Sheng Li Xue Bao. 2015 Oct 25;67(5):455-62.