PMID- 26490432
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20220409
IS  - 1875-6417 (Electronic)
IS  - 1573-3998 (Linking)
VI  - 13
IP  - 1
DP  - 2017
TI  - Family History of Type 2 Diabetes: Does Having a Diabetic Parent Increase the 
      Risk?
PG  - 19-25
LID - 10.2174/1573399812666151022143502 [doi]
AB  - BACKGROUND: It is well established that there is an important genetic 
      predisposition for type 2 diabetes mellitus (T2DM). OBJECTIVE: To summarise 
      available epidemiological data regarding T2DM transmission in various 
      populations. METHOD: Narrative review. RESULTS: The estimated risk for the 
      diagnosis of T2DM increases approximately by 2-4 times, when father, mother or 
      both have this condition. Conversely, many T2DM patients have family members with 
      DM. Studies have suggested that the likelihood of T2DM in the next generation is 
      higher in the event of a diabetic mother than father. Both genetic factors, such 
      as mitochondrial DNA mutations, and environmental components, such as 
      intra-uterine environment, have been implicated in the higher maternal 
      transmission of T2DM. Despite the above findings, some studies in populations 
      with high frequency of T2DM have not corroborated the predominantly maternal 
      transmission. Such works have shown either an excess paternal or an equal 
      transmission of T2DM. CONCLUSION: It appears that potential biases in reporting 
      family history data, especially between the various racial groups, have 
      contributed to the controversy over the existence of excess maternal transmission 
      of DM.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Papazafiropoulou, A K
AU  - Papazafiropoulou AK
AD  - 1 Zanni & Afentouli Street, GR-185 36, Piraeus, Greece.
FAU - Papanas, N
AU  - Papanas N
FAU - Melidonis, A
AU  - Melidonis A
FAU - Maltezos, E
AU  - Maltezos E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Diabetes Rev
JT  - Current diabetes reviews
JID - 101253260
SB  - IM
MH  - Diabetes Mellitus, Type 2/diagnosis/*genetics
MH  - Exercise
MH  - *Family Health
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Obesity
MH  - *Parents
MH  - Risk Factors
OTO - NOTNLM
OT  - Family history
OT  - maternal diabetes
OT  - paternal diabetes
OT  - type 2 diabetes mellitus
EDAT- 2015/10/23 06:00
MHDA- 2017/08/08 06:00
CRDT- 2015/10/23 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2015/10/20 00:00 [revised]
PHST- 2015/10/22 00:00 [accepted]
PHST- 2015/10/23 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
PHST- 2015/10/23 06:00 [entrez]
AID - CDR-EPUB-71203 [pii]
AID - 10.2174/1573399812666151022143502 [doi]
PST - ppublish
SO  - Curr Diabetes Rev. 2017;13(1):19-25. doi: 10.2174/1573399812666151022143502.