PMID- 26490456
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1432-2013 (Electronic)
IS  - 0031-6768 (Linking)
VI  - 468
IP  - 1
DP  - 2016 Jan
TI  - Hypoxia regulates the hematopoietic stem cell niche.
PG  - 13-22
LID - 10.1007/s00424-015-1743-z [doi]
AB  - Bone marrow, the site of hematopoiesis throughout adulthood, is a physiologically 
      hypoxic organ. Thus, various biological oxygen sensors and their signaling 
      cascades play a pivotal role in hematopoietic systems in the bone marrow under 
      both physiologic and pathologic conditions. Hypoxia-inducible factors (HIFs) are 
      hypoxic stress sensor proteins that are stabilized under homeostatic or 
      stress-induced hypoxia. In the hypoxic bone marrow, HIFs play crucial roles in 
      hematopoietic stem cells (HSCs) and in the cells of the HSC niche. The signals 
      downstream of the HIFs maintain HSC quiescence, survival, and metabolic 
      homeostasis through both cell-autonomous and non-cell-autonomous mechanisms. 
      Leukemic stem cells (LSCs) hijack these delicate hypoxia-sensing mechanisms to 
      sustain their self-renewal potential, promoting disease progression and drug 
      resistance even under normoxic conditions. This review focuses on HIF-mediated 
      oxygen-sensing mechanisms of adult HSCs and LSCs and their niche cells in the 
      hypoxic bone marrow.
FAU - Morikawa, Takayuki
AU  - Morikawa T
AD  - Department of Stem Cell Biology, Research Institute, National Center for Global 
      Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
FAU - Takubo, Keiyo
AU  - Takubo K
AD  - Department of Stem Cell Biology, Research Institute, National Center for Global 
      Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. 
      keiyot@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151021
PL  - Germany
TA  - Pflugers Arch
JT  - Pflugers Archiv : European journal of physiology
JID - 0154720
OTO - NOTNLM
OT  - Hematopoietic stem cell
OT  - Hypoxia
OT  - Hypoxia-inducible factor-1alpha
OT  - Leukemic stem cell
OT  - Niche
OT  - Stem cell metabolism
EDAT- 2015/10/23 06:00
MHDA- 2015/10/23 06:01
CRDT- 2015/10/23 06:00
PHST- 2015/09/23 00:00 [received]
PHST- 2015/10/02 00:00 [accepted]
PHST- 2015/09/30 00:00 [revised]
PHST- 2015/10/23 06:00 [pubmed]
PHST- 2015/10/23 06:01 [medline]
PHST- 2015/10/23 06:00 [entrez]
AID - 10.1007/s00424-015-1743-z [pii]
AID - 10.1007/s00424-015-1743-z [doi]
PST - ppublish
SO  - Pflugers Arch. 2016 Jan;468(1):13-22. doi: 10.1007/s00424-015-1743-z. Epub 2015 
      Oct 21.