PMID- 26491904
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1536-4828 (Electronic)
IS  - 0885-3177 (Linking)
VI  - 45
IP  - 4
DP  - 2016 Apr
TI  - Expression of Sex Determining Region Y-Box 2 and Pancreatic and Duodenal Homeobox 
      1 in Pancreatic Neuroendocrine Tumors.
PG  - 522-7
LID - 10.1097/MPA.0000000000000504 [doi]
AB  - OBJECTIVE: The World Health Organization 2010 classification divides pancreatic 
      neuroendocrine tumors (p-NETs) entity to well-differentiated neuroendocrine 
      tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC) by Ki-67 
      index. The aim of this study is elucidate the pathophysiology and tumor biology 
      of p-NETs. METHODS: We assessed the expression of transcription factors sex 
      determining region Y-box 2 (SOX2) and pancreatic and duodenal homeobox 1 (Pdx1)) 
      essential for the normal fetal development of pancreatic neuroendocrine cells in 
      46 surgically resected p-NETs by immunohistochemistry. The relationship of 
      expression levels of these factors and clinicopathological factors were analyzed. 
      RESULTS: SOX2 was positive in 6 p-NETs (13.0%). Five of 7 NEC patients showed 
      positive for SOX2. SOX2 was highly (sensitivity 71%) and specifically 
      (specificity 97%) expressed in NEC. Patients with SOX2 positive p-NET showed the 
      significantly shorter disease-free and overall survival than patients with SOX2 
      negative p-NET. High Pdx1 expression was seen in 25 p-NET patients (54.3%). None 
      of the NEC patients showed high Pdx1 expression. There was a significant reverse 
      correlation between SOX2 and Pdx1 expression. CONCLUSIONS: The expression 
      patterns of SOX2 and Pdx1 highly correlated with prognosis of p-NETs. These 
      expression patterns may represent the biological and pathophysiological 
      difference of p-NETs and indicate the origin of tumor.
FAU - Akiyama, Takahiro
AU  - Akiyama T
AD  - From the Department of General Surgery, Graduate School of Medicine, Chiba 
      University, Chiba City, Chiba, Japan.
FAU - Shida, Takashi
AU  - Shida T
FAU - Yoshitomi, Hideyuki
AU  - Yoshitomi H
FAU - Takano, Shigetsugu
AU  - Takano S
FAU - Kagawa, Shingo
AU  - Kagawa S
FAU - Shimizu, Hiroaki
AU  - Shimizu H
FAU - Ohtsuka, Masayuki
AU  - Ohtsuka M
FAU - Kato, Atsushi
AU  - Kato A
FAU - Furukawa, Katsunori
AU  - Furukawa K
FAU - Miyazaki, Masaru
AU  - Miyazaki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (Trans-Activators)
RN  - 0 (pancreatic and duodenal homeobox 1 protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/biosynthesis
MH  - Chi-Square Distribution
MH  - Female
MH  - Homeodomain Proteins/*biosynthesis
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/*metabolism/pathology
MH  - Pancreatic Neoplasms/*metabolism/pathology
MH  - Prognosis
MH  - SOXB1 Transcription Factors/*biosynthesis
MH  - Trans-Activators/*biosynthesis
EDAT- 2015/10/23 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/10/23 06:00
PHST- 2015/10/23 06:00 [entrez]
PHST- 2015/10/23 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1097/MPA.0000000000000504 [doi]
PST - ppublish
SO  - Pancreas. 2016 Apr;45(4):522-7. doi: 10.1097/MPA.0000000000000504.