PMID- 26493407
OWN - NLM
STAT- MEDLINE
DCOM- 20160927
LR  - 20180408
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 31
IP  - 1
DP  - 2016 Jan
TI  - Exposure of pregnant women to persistent organic pollutants and cord sex hormone 
      levels.
PG  - 190-8
LID - 10.1093/humrep/dev260 [doi]
AB  - STUDY QUESTION: Is prenatal exposure to persistent organic pollutants (POPs) 
      associated with variations of sex hormone levels in cord blood? SUMMARY ANSWER: 
      Prenatal exposure to a number of POPs is associated with a disruption of hormone 
      levels in cord blood, with sex specificities. WHAT IS KNOWN ALREADY: 
      Epidemiological studies have reported disorders of reproductive health, in 
      relation with POPs exposure during early life and the endocrine disruption 
      properties of these chemicals have been suggested as possible mechanisms. STUDY 
      DESIGN, SIZE, DURATION: A subset of 282 mother-child pairs was selected from the 
      prospective population-based PELAGIE birth cohort (n = 3421, 2002-2006, Brittany, 
      France). Pregnant women were recruited before 19 weeks of gestation and followed 
      until delivery. PARTICIPANTS/MATERIALS, SETTING, METHODS: Sex hormone levels 
      including sex hormone-binding globulin (SHBG), estradiol (E2), total testosterone 
      (T), free testosterone (fT = T/SHBG) and the aromatase index (AI = T/E2) were 
      measured in 282 cord blood samples. Anti-Mullerian hormone (AMH) was measured in 
      male newborns only. Pesticide concentrations of alpha-endosulfan, 
      beta-hexachlorocyclohexane (beta-HCH), gamma-HCH, dieldrin, 
      pp'-dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), 
      heptachlor epoxide (HCE), as well as PCBs (congeners 153, 187 and the sum of 
      anti-estrogenic PCBs 118, 138, and 170) and decabrominated diphenyl ether 
      (BDE209) were also measured in cord blood. Associations between sex hormones and 
      POPs exposure were explored using multiple linear regressions adjusted for 
      potential confounders. MAIN RESULTS AND THE ROLE OF CHANCE: High PCB levels were 
      associated with an increase of SHBG (P-trend < 0.01) and AMH (P-trend < 0.05) and 
      a decrease of fT (P-trend < 0.05) and AI (P-trend < 0.01). High pesticide levels, 
      particularly alpha-endosulfan and HCE, were associated with an increase of SHBG (P < 
      0.05) and E2 (P < 0.01) and a decrease of fT (P < 0.05) and AI (P < 0.01). 
      Several of these associations were stronger, or specific, among male or female 
      newborns. The associations were not altered in the sensitivity analyses. 
      LIMITATIONS, REASONS FOR CAUTION: The study population was of relatively small 
      sample size, and some compounds rarely detected in cord blood. The high level of 
      correlation between POPs makes it difficult to identify the most contributing 
      POPs. Hormone measurements were performed at birth (in cord blood) and may not 
      adequately represent the infant endocrine system. Multiple statistical testing 
      may have led to false-positive associations. WIDER IMPLICATIONS OF THE FINDINGS: 
      Our results are in discordance with those reported in the only published study of 
      the kind but in accordance with studies about prenatal exposure to other 
      endocrine disruptors such as phthalates. These findings may help understanding 
      the pathways involved in adverse reproductive outcomes associated with POPs 
      exposure. STUDY FUNDING/COMPETING INTERESTS: The PELAGIE cohort is funded by 
      Inserm, French Ministry of Health, French Ministry of Labor, InVS, ANR, ANSES, 
      and French Ministry of Ecology. None of the authors has any competing interest to 
      declare.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of the European 
      Society of Human Reproduction and Embryology. All rights reserved. For 
      Permissions, please email: journals.permissions@oup.com.
FAU - Warembourg, C
AU  - Warembourg C
AD  - Institut national de la sante et de la recherche medicale (Inserm), U1085, 
      Institut de recherche en sante, environnement et travail (Irset), F-35043 Rennes, 
      France Universite de Rennes 1, F-35043 Rennes, France 
      charline.warembourg@gmail.com.
FAU - Debost-Legrand, A
AU  - Debost-Legrand A
AD  - Institut national de la sante et de la recherche medicale (Inserm), U1085, 
      Institut de recherche en sante, environnement et travail (Irset), F-35043 Rennes, 
      France Centre Hospitalier Universitaire de Clermont-Ferrand, Service de Sante 
      Publique, F-63000 Clermont-Ferrand, France Centre Hospitalier Universitaire de 
      Clermont-Ferrand, EA 4681, PEPRADE, Universite d'Auvergne, F-63000 
      Clermont-Ferrand, France.
FAU - Bonvallot, N
AU  - Bonvallot N
AD  - Institut national de la sante et de la recherche medicale (Inserm), U1085, 
      Institut de recherche en sante, environnement et travail (Irset), F-35043 Rennes, 
      France Ecole des hautes etudes en sante publique (EHESP), F-35043 Rennes, France.
FAU - Massart, C
AU  - Massart C
AD  - Centre de Toxicologie du Quebec of the National Institute of Public Health, 
      Quebec, Canada.
FAU - Garlantezec, R
AU  - Garlantezec R
AD  - Institut national de la sante et de la recherche medicale (Inserm), U1085, 
      Institut de recherche en sante, environnement et travail (Irset), F-35043 Rennes, 
      France Ecole des hautes etudes en sante publique (EHESP), F-35043 Rennes, France.
FAU - Monfort, C
AU  - Monfort C
AD  - Institut national de la sante et de la recherche medicale (Inserm), U1085, 
      Institut de recherche en sante, environnement et travail (Irset), F-35043 Rennes, 
      France Universite de Rennes 1, F-35043 Rennes, France.
FAU - Gaudreau, E
AU  - Gaudreau E
AD  - Centre Hospitalier Universitaire de Rennes, Unite fonctionnelle d'hormonologie, 
      Inserm U1414, Centre d'Investigation Clinique, F-35033 Rennes, France.
FAU - Chevrier, C
AU  - Chevrier C
AD  - Institut national de la sante et de la recherche medicale (Inserm), U1085, 
      Institut de recherche en sante, environnement et travail (Irset), F-35043 Rennes, 
      France Universite de Rennes 1, F-35043 Rennes, France.
FAU - Cordier, S
AU  - Cordier S
AD  - Institut national de la sante et de la recherche medicale (Inserm), U1085, 
      Institut de recherche en sante, environnement et travail (Irset), F-35043 Rennes, 
      France Universite de Rennes 1, F-35043 Rennes, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151022
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
CIN - Hum Reprod. 2017 Jun 1;32(6):1363. PMID: 28453619
CIN - Hum Reprod. 2017 Jun 1;32(6):1360. PMID: 28453632
MH  - Adult
MH  - Biphenyl Compounds/*adverse effects
MH  - Endocrine Disruptors/*adverse effects
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - Follow-Up Studies
MH  - Gonadal Steroid Hormones/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*adverse effects
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - Sex Factors
OTO - NOTNLM
OT  - cohort studies
OT  - endocrine disruptors
OT  - hormones
OT  - newborns
OT  - organochlorine compounds
OT  - polychlorinated biphenyls
OT  - steroids
EDAT- 2015/10/24 06:00
MHDA- 2016/09/28 06:00
CRDT- 2015/10/24 06:00
PHST- 2015/02/12 00:00 [received]
PHST- 2015/09/22 00:00 [accepted]
PHST- 2015/10/24 06:00 [entrez]
PHST- 2015/10/24 06:00 [pubmed]
PHST- 2016/09/28 06:00 [medline]
AID - dev260 [pii]
AID - 10.1093/humrep/dev260 [doi]
PST - ppublish
SO  - Hum Reprod. 2016 Jan;31(1):190-8. doi: 10.1093/humrep/dev260. Epub 2015 Oct 22.