PMID- 26495021
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151023
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2015
DP  - 2015
TI  - Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells 
      and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice.
PG  - 678487
LID - 10.1155/2015/678487 [doi]
LID - 678487
AB  - This study investigated the immunomodulatory effects of ferulic acid (FA) on 
      antigen-presenting dendritic cells (DCs) in vitro and its antiallergic effects 
      against ovalbumin- (OVA-) induced Th2-mediated allergic asthma in mice. The 
      activation of FA-treated bone marrow-derived DCs by lipopolysaccharide (LPS) 
      stimulation induced a high level of interleukin- (IL-) 12 but reduced the 
      expression levels of the proinflammatory cytokines IL-1beta, IL-6, and tumor 
      necrosis factor- (TNF-) alpha. Compared to control-treated DCs, FA significantly 
      enhanced the expressions of Notch ligand Delta-like 4 (Dll4), MHC class II, and 
      CD40 molecules by these DCs. Furthermore, these FA-treated DCs enhanced T-cell 
      proliferation and Th1 cell polarization. In animal experiments, oral 
      administration of FA reduced the levels of OVA-specific immunoglobulin E (IgE) 
      and IgG1 and enhanced IgG2a antibody production in serum. It also ameliorated 
      airway hyperresponsiveness and attenuated eosinophilic pulmonary infiltration in 
      dose-dependent manners. In addition, FA treatment inhibited the production of 
      eotaxin, Th2 cytokines (IL-4, IL-5, and IL-13), and proinflammatory cytokines but 
      promoted the Th1 cytokine interferon- (IFN-) gamma production in bronchoalveolar 
      lavage fluid (BALF) and the culture supernatant of spleen cells. These findings 
      suggest that FA exhibits an antiallergic effect via restoring Th1/Th2 imbalance 
      by modulating DCs function in an asthmatic mouse model.
FAU - Lee, Chen-Chen
AU  - Lee CC
AD  - Department of Microbiology and Immunology, School of Medicine, China Medical 
      University, Taichung 40402, Taiwan.
FAU - Wang, Ching-Chiung
AU  - Wang CC
AD  - School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, 
      Taiwan.
FAU - Huang, Huei-Mei
AU  - Huang HM
AD  - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical 
      University, Taipei 11031, Taiwan.
FAU - Lin, Chu-Lun
AU  - Lin CL
AD  - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical 
      University, Taipei 11031, Taiwan.
FAU - Leu, Sy-Jye
AU  - Leu SJ
AD  - Department of Microbiology and Immunology, College of Medicine, Taipei Medical 
      University, Taipei 11031, Taiwan.
FAU - Lee, Yueh-Lun
AU  - Lee YL
AD  - Department of Microbiology and Immunology, College of Medicine, Taipei Medical 
      University, Taipei 11031, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20151001
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
EIN - Evid Based Complement Alternat Med. 2017;2017:1039829. PMID: 29085433
PMC - PMC4606409
EDAT- 2015/10/27 06:00
MHDA- 2015/10/27 06:01
PMCR- 2015/10/01
CRDT- 2015/10/24 06:00
PHST- 2015/06/18 00:00 [received]
PHST- 2015/09/02 00:00 [accepted]
PHST- 2015/10/24 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2015/10/27 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 10.1155/2015/678487 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2015;2015:678487. doi: 10.1155/2015/678487. 
      Epub 2015 Oct 1.