PMID- 26495134
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151023
LR  - 20240325
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2015
DP  - 2015
TI  - Safety and Efficacy of Adding Fixed-Combination Brinzolamide/Timolol Maleate to 
      Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma.
PG  - 131970
LID - 10.1155/2015/131970 [doi]
LID - 131970
AB  - Purpose. To evaluate the safety and efficacy of adding brinzolamide 1%/timolol 
      maleate 0.5% fixed combination (BTFC) to a prostaglandin analog (PGA). Methods. 
      This was a 12-week, open-label, single-arm study of patients with open-angle 
      glaucoma or ocular hypertension with intraocular pressure (IOP) not sufficiently 
      controlled after >/=4 weeks of PGA monotherapy. The primary outcome was mean IOP 
      change from baseline at week 12. Other outcomes included IOP change from baseline 
      at week 4, percentage of patients achieving IOP </=18 mmHg at week 12, and patient 
      experience survey responses at week 12. Results. Forty-seven patients were 
      enrolled and received treatment. The most commonly used PGAs were latanoprost 
      (47%) and travoprost (32%). Mean +/- SD IOP was decreased at week 12 (17.2 +/- 
      4.1 mmHg) compared with baseline (23.1 +/- 3.0 mmHg; P < 0.001, paired t-test); IOP 
      at week 4 was 17.2 +/- 3.3 mmHg. At week 12, 70% of patients achieved IOP </=18 mmHg. 
      Patient-reported symptoms (e.g., pain and redness) were mostly unchanged from 
      baseline. Twenty-eight adverse events (AEs) were reported; the most frequently 
      reported AE was headache (3 events in 2 patients). Conclusion. Adjunctive BTFC + 
      PGA therapy was effective and well tolerated. IOP decreased by 6 mmHg at weeks 4 
      and 12.
FAU - Hommer, Anton
AU  - Hommer A
AD  - Private Office, Vienna, Austria.
FAU - Hubatsch, Douglas A
AU  - Hubatsch DA
AD  - Alcon Laboratories, Inc., Fort Worth, TX 76134, USA.
FAU - Cano-Parra, Juan
AU  - Cano-Parra J
AD  - Hospital Municipal de Badalona, 08911 Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20151001
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC4606181
EDAT- 2015/10/27 06:00
MHDA- 2015/10/27 06:01
PMCR- 2015/10/01
CRDT- 2015/10/24 06:00
PHST- 2015/06/12 00:00 [received]
PHST- 2015/08/19 00:00 [accepted]
PHST- 2015/10/24 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2015/10/27 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 10.1155/2015/131970 [doi]
PST - ppublish
SO  - J Ophthalmol. 2015;2015:131970. doi: 10.1155/2015/131970. Epub 2015 Oct 1.