PMID- 26497005
OWN - NLM
STAT- MEDLINE
DCOM- 20161219
LR  - 20220316
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 105
IP  - 4
DP  - 2016 Apr
TI  - Long-term outcome of patients with and without super-response to CRT-D.
PG  - 341-8
LID - 10.1007/s00392-015-0926-0 [doi]
AB  - OBJECTIVE: To compare outcome between patients with and without super-response to 
      cardiac resynchronization therapy-defibrillator (CRT-D). METHODS AND RESULTS: In 
      this cohort study, 167 consecutive CRT-D candidates were included. Super-response 
      to CRT-D was defined clinically [improvement of >/=1 New York Heart Association 
      (NYHA) class or >/=50 m in six-minute walk distance (6MWD)] and 
      echocardiographically [increase of left ventricular ejection fraction (LVEF) >/=1 
      category (LVEF <30 to 30-40 % or 30-40 to 41-51 %) or reduction of left 
      ventricular end-diastolic diameter (LVEDD) >/=10 mm]. Clinical outcome (death, 
      cardiac transplantation and appropriate shock therapy) was compared between 
      super-responders (n = 32) and non-super-responders (n = 135). During follow-up 
      (616 patient-years; median 3.3 years), all-cause mortality was significantly 
      lower in super-responders compared to non-super-responders (log rank p < 0.05). 
      At least one appropriate shock was noted in 22 % of super-responders and 39 % of 
      non-super-responders (p = 0.069). Time to appropriate shock therapy was 
      significantly longer in super-responders (log rank p < 0.05). Event-free survival 
      from death or cardiac transplantation was comparable between the two groups. 
      CONCLUSION: Super-response to CRT-D is associated with improved survival and 
      lower risk of appropriate shock therapy compared to non-super-responders. Further 
      information about the mechanisms of super-response and its long-term consequences 
      are needed to foresee favorable outcome after implantation of CRT-D.
FAU - Franke, Jennifer
AU  - Franke J
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany. Jennifer.Franke@med.uni-heidelberg.de.
FAU - Keppler, Jeannette
AU  - Keppler J
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
FAU - Abadei, Alamara Karimi
AU  - Abadei AK
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
FAU - Bajrovic, Amer
AU  - Bajrovic A
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
FAU - Meme, Lillian
AU  - Meme L
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
FAU - Zugck, Christian
AU  - Zugck C
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
FAU - Raake, Philip W
AU  - Raake PW
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
FAU - Zitron, Edgar
AU  - Zitron E
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
FAU - Katus, Hugo A
AU  - Katus HA
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
FAU - Frankenstein, Lutz
AU  - Frankenstein L
AD  - Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 
      69120, Heidelberg, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20151023
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cardiac Resynchronization Therapy/adverse effects/mortality
MH  - Cardiac Resynchronization Therapy Devices
MH  - Chronic Disease
MH  - Defibrillators, Implantable
MH  - Disease-Free Survival
MH  - *Electric Countershock/adverse effects/instrumentation/mortality
MH  - Female
MH  - Heart Failure/diagnosis/mortality/physiopathology/*therapy
MH  - Heart Transplantation
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Registries
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac resynchronization therapy-defibrillator
OT  - Chronic heart failure
OT  - Long-term outcome
OT  - Super-response
EDAT- 2015/10/27 06:00
MHDA- 2016/12/20 06:00
CRDT- 2015/10/27 06:00
PHST- 2015/07/07 00:00 [received]
PHST- 2015/10/15 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/12/20 06:00 [medline]
AID - 10.1007/s00392-015-0926-0 [pii]
AID - 10.1007/s00392-015-0926-0 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2016 Apr;105(4):341-8. doi: 10.1007/s00392-015-0926-0. Epub 
      2015 Oct 23.