PMID- 26497589
OWN - NLM
STAT- MEDLINE
DCOM- 20160804
LR  - 20181113
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 11
DP  - 2015 Oct 24
TI  - Unusual severe cases of type 1 porcine reproductive and respiratory syndrome 
      virus (PRRSV) infection in conventionally reared pigs in South Korea.
PG  - 272
LID - 10.1186/s12917-015-0584-5 [doi]
LID - 272
AB  - BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) causes a 
      loss of approximately US$ 70 million every year to the South Korean pork 
      industry. There are two distinct genotypes: European (type 1) and North American 
      (type 2). In South Korea, type 1 and type 2 PRRSV are widely distributed and have 
      evolved continuously since the infection was first described. Here, we present 
      two field cases of type 1 PRRSV infection with unusually severe pathogenicity. 
      CASE PRESENTATION: The first case farm was a two-site production system 
      comprising farrow-to-grower and grower-to-finish units and was historically free 
      from PRRSV infections. The PRRSV vaccine had not been used in both units. In 
      October 2014, pigs in the grower-to-finish unit experienced severe respiratory 
      distress with the mortality rate reaching to 22%. Despite antibiotic treatment, 
      clinical signs were still noticed in most pigs. The second case farm was also a 
      two-site production system, but had two separate farrow-to-grower units (unit A 
      and unit B). Historically, type 1 PRRSV was continuously present in unit A, but 
      unit B was free from PRRSV. Thus, all grower pigs of unit B were vaccinated 
      before being moved to the grower-to-finish unit. In November 2014, severe 
      respiratory distress was seen in pigs of the grower-to-finish unit. Significant 
      respiratory distress was observed in only the grower herd moved from unit B, and 
      the mortality of those pigs was ~50%. However, no disease was shown in the grower 
      pigs from unit A. CONCLUSIONS: To our knowledge, the present study is the first 
      observation of the cases of infection by highly pathogenic type 1 PRRSV in South 
      Korea. The Korean type 1 PRRSV strains have undergone unique evolutionary 
      dynamics for the last decade in this country. Although there are known to be 
      three clusters of Korean type 1 PRRSV, their pathogenicity could not be 
      categorized owing to their high level of genetic diversity. Therefore, further 
      studies are needed to demonstrate the novel classification of Korean type 1 PRRSV 
      strains according to their virulence factors.
FAU - Lyoo, Kwang-Soo
AU  - Lyoo KS
AD  - Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South 
      Korea. lks1314@jbnu.ac.kr.
FAU - Yeom, Minjoo
AU  - Yeom M
AD  - Department of Pharmacy, College of Pharmacy, Korea University, Sejong, South 
      Korea. paransearo@naver.com.
FAU - Choi, Jong-Young
AU  - Choi JY
AD  - Dodam Veterinary Clinic, Seoul, South Korea. vetcjy@hanmail.net.
FAU - Park, Jong-Hwan
AU  - Park JH
AD  - College of Veterinary Medicine, Jeonnam National University, Gwangju, South 
      Korea. jonpark94@naver.com.
FAU - Yoon, Sun-Woo
AU  - Yoon SW
AD  - Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea. 
      syoon@kribb.re.kr.
FAU - Song, Daesub
AU  - Song D
AD  - Department of Pharmacy, College of Pharmacy, Korea University, Sejong, South 
      Korea. sds1@korea.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151024
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
SB  - IM
MH  - Animal Husbandry/*methods
MH  - Animals
MH  - Genotype
MH  - Lung/pathology
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*pathology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/pathogenicity
MH  - Republic of Korea/epidemiology
MH  - Swine
MH  - Virulence
PMC - PMC4619543
EDAT- 2015/10/27 06:00
MHDA- 2016/08/05 06:00
PMCR- 2015/10/24
CRDT- 2015/10/27 06:00
PHST- 2015/07/21 00:00 [received]
PHST- 2015/10/15 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/08/05 06:00 [medline]
PHST- 2015/10/24 00:00 [pmc-release]
AID - 10.1186/s12917-015-0584-5 [pii]
AID - 584 [pii]
AID - 10.1186/s12917-015-0584-5 [doi]
PST - epublish
SO  - BMC Vet Res. 2015 Oct 24;11:272. doi: 10.1186/s12917-015-0584-5.