PMID- 26497858
OWN - NLM
STAT- MEDLINE
DCOM- 20160922
LR  - 20211203
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 12
IP  - 6
DP  - 2015 Dec
TI  - Mammalian target of rapamycin/p70 ribosomal S6 protein kinase signaling is 
      altered by sevoflurane and/or surgery in aged rats.
PG  - 8253-60
LID - 10.3892/mmr.2015.4444 [doi]
AB  - The mammalian target of rapamycin (mTOR)/p70 ribosomal S6 protein kinase (p70S6k) 
      pathway exerts anti‑apoptotic effects that may contribute to disease 
      pathogenesis. The memory impairment in patients with Alzheimer's disease (AD) has 
      been suggested to be contributed to by abnormal mTOR signaling. The aim of the 
      current study was to investigate the association between sevoflurane and/or 
      surgery and AD through the mTOR/p70S6K signaling pathway. Sprague‑Dawley rats 
      were randomly assigned to the sevoflurane, surgery or control groups. The animals 
      in the surgery group received a partial hepatectomy under sevoflurane anesthesia. 
      The hippocampal levels of phosphorylated (p)‑mTOR, p‑p70S6K, caspase‑3 and 
      p‑tau/total (t)‑tau were analyzed. The Morris water maze (MWM) was used to 
      evaluate cognitive function following treatment. The levels of p‑mTOR and 
      p‑p70S6K were reduced, whereas caspase‑3 levels were increased in the surgery 
      group compared with the sevoflurane group. The p‑tau/t‑tau levels were increased, 
      however, tau mRNA was unaffected by sevoflurane and/or surgery. The rats in the 
      surgery group required a significantly longer time to locate the platform in the 
      MWM test compared with the control and sevoflurane groups. Sevoflurane treatment 
      and/or surgery reduced anti‑apoptotic activity, and the postoperative cognitive 
      dysfunction following surgery may be due to mTOR signaling pathway inhibition in 
      aged rats. Increased neuronal apoptosis and tau phosphorylation are suggested to 
      be involved in the association between anesthesia and AD occurrence.
FAU - Liu, Yongzhe
AU  - Liu Y
AD  - Department of Anesthesiology, Beijing Military General Hospital, Beijing 100700, 
      P.R. China.
FAU - Ma, Li
AU  - Ma L
AD  - Department of Anesthesiology, Beijing Military General Hospital, Beijing 100700, 
      P.R. China.
FAU - Jiao, Linbo
AU  - Jiao L
AD  - Department of Anesthesiology, Beijing Military General Hospital, Beijing 100700, 
      P.R. China.
FAU - Gao, Minglong
AU  - Gao M
AD  - Department of Anesthesiology, Beijing Military General Hospital, Beijing 100700, 
      P.R. China.
FAU - Guo, Wenzhi
AU  - Guo W
AD  - Department of Anesthesiology, Beijing Military General Hospital, Beijing 100700, 
      P.R. China.
FAU - Chen, Lin
AU  - Chen L
AD  - Department of Anesthesiology, Beijing Military General Hospital, Beijing 100700, 
      P.R. China.
FAU - Pan, Ningling
AU  - Pan N
AD  - Department of Anesthesiology, Beijing Military General Hospital, Beijing 100700, 
      P.R. China.
FAU - Ma, Yaqun
AU  - Ma Y
AD  - Department of Anesthesiology, Beijing Military General Hospital, Beijing 100700, 
      P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151014
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Anesthetics)
RN  - 0 (Mapt protein, rat)
RN  - 0 (Methyl Ethers)
RN  - 0 (tau Proteins)
RN  - 38LVP0K73A (Sevoflurane)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Anesthetics/adverse effects/*pharmacology
MH  - Animals
MH  - Female
MH  - Hepatectomy/adverse effects
MH  - Hippocampus/metabolism
MH  - Maze Learning
MH  - Methyl Ethers/adverse effects/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ribosomal Protein S6 Kinases, 70-kDa/*metabolism
MH  - Sevoflurane
MH  - Signal Transduction/*drug effects
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - tau Proteins/metabolism
EDAT- 2015/10/27 06:00
MHDA- 2016/09/23 06:00
CRDT- 2015/10/27 06:00
PHST- 2014/10/25 00:00 [received]
PHST- 2015/09/28 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - 10.3892/mmr.2015.4444 [doi]
PST - ppublish
SO  - Mol Med Rep. 2015 Dec;12(6):8253-60. doi: 10.3892/mmr.2015.4444. Epub 2015 Oct 
      14.