PMID- 26498390
OWN - NLM
STAT- MEDLINE
DCOM- 20160916
LR  - 20151216
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 85
IP  - 2
DP  - 2016 Jan 15
TI  - Total plasma magnesium in healthy and critically ill foals.
PG  - 180-5
LID - S0093-691X(15)00482-3 [pii]
LID - 10.1016/j.theriogenology.2015.09.011 [doi]
AB  - Abnormalities in total Mg (tMg) concentration in plasma and/or serum are common 
      in critically ill humans, and the association with increased mortality has been 
      documented in several clinical studies in adults and newborns with 
      hypoxic-ischemic encephalopathy. Abnormalities in tMg were studied in 
      hospitalized dogs, cats, and adult horses. Newborn foals were scarcely studied 
      with regard to Mg concentration. The aims of the present study were: (1) to 
      compare two analytical methods for the determination of tMg in plasma: the 
      automated colorimetric method and the atomic absorption spectrometry; (2) to 
      measure plasma tMg in healthy foals during the first 72 hours after birth and in 
      sick foals during the first 72 hours of hospitalization; (3) to compare total 
      plasma Mg concentration among healthy foals, foals affected by perinatal asphyxia 
      syndrome (PAS), prematurity and/or dismaturity, and sepsis; (4) to evaluate tMg 
      plasma concentration in surviving and non-surviving foals. One hundred seventeen 
      foals were included in the study: 20 healthy and 97 sick foals. The automated 
      method used in clinical practice probably overestimates plasma tMg. Due to its 
      higher sensitivity and specificity, the atomic absorption spectrometry should be 
      considered the method of choice from an analytical point of view, but requires an 
      instrumentation not easily available in any laboratory and specific technical 
      skills and competencies. Plasma tMg in healthy foals were included in the range 
      0.52 to 1.01 mmol/L and did not show any time-dependent change during the first 
      72 hours of life. In sick foals, tMg evaluated at T0 was statistically higher 
      than tMg measured at subsequent times. Foals affected by PAS had a tMg at T0 
      significantly higher (P < 0.01) than healthy, septic, and premature and/or 
      dysmature foals. The t test found significantly higher (P < 0.01) plasma tMg 
      measured at T0 in non-surviving than in surviving foals. Plasma tMg could be a 
      useful parameter for the diagnosis of PAS and the formulation of the prognosis in 
      critically ill foals.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Mariella, J
AU  - Mariella J
AD  - Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy. 
      Electronic address: jole.mariella2@unibo.it.
FAU - Isani, G
AU  - Isani G
AD  - Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
FAU - Andreani, G
AU  - Andreani G
AD  - Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
FAU - Freccero, F
AU  - Freccero F
AD  - Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
FAU - Carpene, E
AU  - Carpene E
AD  - Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
FAU - Castagnetti, C
AU  - Castagnetti C
AD  - Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150910
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*blood
MH  - Asphyxia Neonatorum/blood/veterinary
MH  - Colorimetry/methods/veterinary
MH  - False Positive Reactions
MH  - Horse Diseases/*blood
MH  - Horses/*blood
MH  - Magnesium/*blood
MH  - Premature Birth/blood/veterinary
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Sepsis/blood
MH  - Spectrophotometry, Atomic/methods/veterinary
OTO - NOTNLM
OT  - Atomic absorption spectrometry
OT  - Critically ill
OT  - Foal
OT  - Magnesium
OT  - Perinatal asphyxia syndrome
EDAT- 2015/10/27 06:00
MHDA- 2016/09/17 06:00
CRDT- 2015/10/27 06:00
PHST- 2014/09/08 00:00 [received]
PHST- 2015/08/27 00:00 [revised]
PHST- 2015/09/03 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/09/17 06:00 [medline]
AID - S0093-691X(15)00482-3 [pii]
AID - 10.1016/j.theriogenology.2015.09.011 [doi]
PST - ppublish
SO  - Theriogenology. 2016 Jan 15;85(2):180-5. doi: 
      10.1016/j.theriogenology.2015.09.011. Epub 2015 Sep 10.