PMID- 26498537
OWN - NLM
STAT- MEDLINE
DCOM- 20160920
LR  - 20161126
IS  - 1875-2128 (Electronic)
IS  - 1875-2128 (Linking)
VI  - 108
IP  - 12
DP  - 2015 Dec
TI  - Circulating microribonucleic acids miR-1, miR-21 and miR-208a in patients with 
      symptomatic heart failure: Preliminary results.
PG  - 634-42
LID - S1875-2136(15)00153-9 [pii]
LID - 10.1016/j.acvd.2015.07.003 [doi]
AB  - BACKGROUND: Cardiomyocytes produce a wide variety of bioactive molecules that 
      regulate numerous physiological and pathophysiological processes. Recently, it 
      has been recognized that changes in microribonucleic acid (miRNA) expression may 
      lead to cardiac dysfunction. AIMS: To assess the expression of circulating miRNAs 
      (miR-1, miR-21 and miR-208a) in patients with symptomatic heart failure (HF), and 
      to investigate the relationship between expression of these miRNAs and secretion 
      of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and galectin-3. METHODS: 
      Thirty-five patients in New York Heart Association (NYHA) class II/III (age: 68.8 
      +/- 13.0 years) and 26 patients in NYHA class IV (age: 72.0 +/- 10.4 years) 
      hospitalized in the intensive coronary care unit participated in the study. Serum 
      concentrations of miRNAs were measured by quantitative real-time polymerase chain 
      reaction. Basic biochemical assays were carried out, and NT-proBNP and galectin-3 
      concentrations were measured in all serum samples. RESULTS: miR-1 was 
      downregulated in patients with symptomatic HF and its expression decreased with 
      severity of NYHA class (P=0.007). In contrast, overexpression of miR-21 was seen 
      in all patients, independent of HF severity. Results suggest no miR-208a leakage 
      into the circulation in patients with symptomatic HF. There was an inverse 
      relationship between miR-1 expression and NT-proBNP concentration (Spearman's 
      rank correlation coefficient [r]=-0.389; P=0.023) in patients in NYHA class 
      II/III. Overexpression of miR-21 correlated significantly with galectin-3 
      concentration (r=0.422; P=0.032). CONCLUSION: Dysregulation of miR-1 and miR-21 
      expression may be essential for the development of HF; miR-1 might become a 
      biomarker for predicting HF exacerbation.
CI  - Copyright (c) 2015 Elsevier Masson SAS. All rights reserved.
FAU - Sygitowicz, Grazyna
AU  - Sygitowicz G
AD  - Department of Laboratory Medical Diagnostics, Medical University of Warsaw, 
      Warsaw, Poland. Electronic address: gsygitowicz@poczta.onet.pl.
FAU - Tomaniak, Mariusz
AU  - Tomaniak M
AD  - 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, 
      Poland.
FAU - Blaszczyk, Olga
AU  - Blaszczyk O
AD  - Department of Pharmacogenomics, Medical University of Warsaw, Warsaw, Poland.
FAU - Koltowski, Lukasz
AU  - Koltowski L
AD  - 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, 
      Poland.
FAU - Filipiak, Krzysztof J
AU  - Filipiak KJ
AD  - 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, 
      Poland.
FAU - Sitkiewicz, Dariusz
AU  - Sitkiewicz D
AD  - Department of Laboratory Medical Diagnostics, Medical University of Warsaw, 
      Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151021
PL  - Netherlands
TA  - Arch Cardiovasc Dis
JT  - Archives of cardiovascular diseases
JID - 101465655
RN  - 0 (Biomarkers)
RN  - 0 (MIRN1 microRNA, human)
RN  - 0 (MIRN208 microRNA, human)
RN  - 0 (MIRN21 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*blood/diagnostic imaging/genetics
MH  - Humans
MH  - Male
MH  - MicroRNAs/*blood
MH  - RNA/*genetics
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
OTO - NOTNLM
OT  - ARN-m
OT  - Cardiovascular disease
OT  - Galectin-3
OT  - Galectine-3
OT  - Heart failure
OT  - Insuffisance cardiaque
OT  - Maladie cardiovasculaire
OT  - Microribonucleic acid
OT  - NT-pro-BNP
OT  - NT-proBNP
EDAT- 2015/10/27 06:00
MHDA- 2016/09/22 06:00
CRDT- 2015/10/27 06:00
PHST- 2015/01/13 00:00 [received]
PHST- 2015/07/08 00:00 [revised]
PHST- 2015/07/22 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/09/22 06:00 [medline]
AID - S1875-2136(15)00153-9 [pii]
AID - 10.1016/j.acvd.2015.07.003 [doi]
PST - ppublish
SO  - Arch Cardiovasc Dis. 2015 Dec;108(12):634-42. doi: 10.1016/j.acvd.2015.07.003. 
      Epub 2015 Oct 21.