PMID- 26498879
OWN - NLM
STAT- MEDLINE
DCOM- 20160922
LR  - 20220317
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1629
DP  - 2015 Dec 10
TI  - Nesfatin-1, a potent anorexic agent, decreases exploration and induces 
      anxiety-like behavior in rats without altering learning or memory.
PG  - 171-81
LID - S0006-8993(15)00788-X [pii]
LID - 10.1016/j.brainres.2015.10.027 [doi]
AB  - The anorectic neuropeptide nesfatin-1 has recently been characterized as a 
      potential mood regulator, but the accurate effect of nesfatin-1 on anxiety and 
      learning and memory behavior and the possible mechanisms remains unknown. In the 
      present study, to test the hypothesis that nesfatin-1 might affect the 
      anxiety-like and learning and memory behaviors in rats via ERK/CREB/BDNF pathway, 
      nesfatin-1 was administered intraperitoneally to rats with the doses (10, 20, 
      40mug/kg), and the behavioral performance was tested using the open field task, 
      the Morris water maze (MWM), and the Y maze. Moreover, the protein expression of 
      brain-derived neurotrophic factor (BDNF), total and phosphorylated-ERK in the 
      hippocampus and the prefrontal cortex (PFC) were evaluated. The results showed 
      that chronic administration of nesfatin-1 could decrease the moving distance, the 
      duration in the center, and the frequencies of rearing and grooming in the open 
      field task, decrease the moving distance, frequency, and the preference index of 
      new arm in the Y maze, although there was no significant difference of the 
      performance in the MWM task among groups. Furthermore, 3 weeks' consecutive 
      administration of nesfatin-1 resulted in the decrease of protein expression of 
      BDNF and phosphorylated-ERK in the hippocampus and the PFC. These results 
      provided evidence that exogenous nesfatin-1 could decrease exploration and induce 
      anxiety-like behavior in rats, the mechanism of which might be related to the 
      reduced protein expression of BDNF and phosphorylated-ERK in the hippocampus and 
      the PFC.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ge, Jin-Fang
AU  - Ge JF
AD  - Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, 
      Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, Anhui, China. 
      Electronic address: gejinfang@ahmu.edu.cn.
FAU - Xu, Ya-Yun
AU  - Xu YY
AD  - Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, 
      Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, Anhui, China.
FAU - Qin, Gan
AU  - Qin G
AD  - Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, 
      Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, Anhui, China.
FAU - Pan, Xue-Yin
AU  - Pan XY
AD  - Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, 
      Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, Anhui, China.
FAU - Cheng, Jiang-Qun
AU  - Cheng JQ
AD  - Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, 
      Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, Anhui, China.
FAU - Chen, Fei-Hu
AU  - Chen FH
AD  - Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, 
      Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, Anhui, China. 
      Electronic address: cfhchina@sohu.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151021
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Appetite Depressants)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nucb1 protein, rat)
RN  - 0 (Nucleobindins)
SB  - IM
MH  - Animals
MH  - Anxiety/*chemically induced/psychology
MH  - Appetite Depressants/*toxicity
MH  - Calcium-Binding Proteins/*toxicity
MH  - DNA-Binding Proteins/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Exploratory Behavior/*drug effects/physiology
MH  - Male
MH  - Maze Learning/*drug effects/physiology
MH  - Memory Disorders/*chemically induced/psychology
MH  - Nerve Tissue Proteins/*toxicity
MH  - Nucleobindins
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Anxiety
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Morris water maze (MWM)
OT  - Nesfatin-1
OT  - Rat
OT  - Y maze
EDAT- 2015/10/27 06:00
MHDA- 2016/09/23 06:00
CRDT- 2015/10/27 06:00
PHST- 2015/06/10 00:00 [received]
PHST- 2015/10/09 00:00 [revised]
PHST- 2015/10/15 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - S0006-8993(15)00788-X [pii]
AID - 10.1016/j.brainres.2015.10.027 [doi]
PST - ppublish
SO  - Brain Res. 2015 Dec 10;1629:171-81. doi: 10.1016/j.brainres.2015.10.027. Epub 
      2015 Oct 21.