PMID- 26499137
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20161230
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 7
IP  - 1
DP  - 2016 Jan
TI  - Protective effects of trigonelline against indomethacin-induced gastric ulcer in 
      rats and potential underlying mechanisms.
PG  - 398-408
LID - 10.1039/c5fo00403a [doi]
AB  - The present study was undertaken to explore gastroprotective effects of 
      trigonelline (TRG) and to determine the potential mechanisms involved in this 
      action. In order to evaluate the gastroprotective efficiency of TRG, an 
      indomethacin-induced ulcer model has been applied. Antioxidants, cytokines, 
      adhesion markers and apoptosis levels have been analyzed for the biochemical 
      mechanism involved in TRG activity. TRG (45 mg kg(-1)) pretreated rats 
      significantly inhibited gastric lesions by 81.71%. Indomethacin administration 
      raises the levels of leukotriene B4 (LTB4), lipid peroxidation and 
      myeloperoxidase (MPO) with the significant declines of prostaglandin E2 (PGE2), 
      superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-px) 
      levels. Conversely, TRG (45 mg kg(-1)) pretreated animals showed significant 
      rises in PGE2 and antioxidant levels along with substantial reductions in LTB4, 
      lipid peroxidation and MPO levels. Indomethacin-induced rats also exhibited 
      considerable increases of pro-inflammatory cytokines including interleukin-6 
      (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma 
      (IFN-gamma) levels and decreases of anti-inflammatory cytokines such as 
      interleukin-10 (IL-10) and interleukin-4 (IL-4), but these imbalances were 
      normalized through treatment of TRG. The protective activity of TRG against 
      indomethacin-induced gastric ulcer has been ascribed to three important 
      mechanisms: (1) anti-inflammatory; (2) antioxidant; (3) anti-apoptotic pathways.
FAU - Antonisamy, Paulrayer
AU  - Antonisamy P
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, 54596 79 Gobong-ro, Iksan-city, Jeollabuk-Do, Republic of Korea. 
      jhkim1@jbnu.ac.kr.
FAU - Arasu, Mariadhas Valan
AU  - Arasu MV
AD  - Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, 
      College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi 
      Arabia.
FAU - Dhanasekaran, Muniappan
AU  - Dhanasekaran M
AD  - Division of Ethnopharmacology, Entomology Research Institute, Loyola College, 
      Chennai 600 034, Tamil Nadu, India.
FAU - Choi, Ki Choon
AU  - Choi KC
AD  - Grassland and forage division, National Institute of Animal Science, RDA, 
      Seonghwan-Eup, Cheonan-Si, Chungnam 330-801, Republic of Korea.
FAU - Aravinthan, Adithan
AU  - Aravinthan A
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, 54596 79 Gobong-ro, Iksan-city, Jeollabuk-Do, Republic of Korea. 
      jhkim1@jbnu.ac.kr.
FAU - Kim, Nam Soo
AU  - Kim NS
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, 54596 79 Gobong-ro, Iksan-city, Jeollabuk-Do, Republic of Korea. 
      jhkim1@jbnu.ac.kr.
FAU - Kang, Chang-Won
AU  - Kang CW
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, 54596 79 Gobong-ro, Iksan-city, Jeollabuk-Do, Republic of Korea. 
      jhkim1@jbnu.ac.kr.
FAU - Kim, Jong-Hoon
AU  - Kim JH
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, 54596 79 Gobong-ro, Iksan-city, Jeollabuk-Do, Republic of Korea. 
      jhkim1@jbnu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Alkaloids)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Pyrazoles)
RN  - 0 (SC 560)
RN  - 3NQ9N60I00 (trigonelline)
RN  - O3C74ACM9V (Ethylmaleimide)
RN  - SX6K58TVWC (Glyburide)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Alkaloids/*pharmacology
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*toxicity
MH  - Anti-Ulcer Agents/*pharmacology
MH  - Ethylmaleimide
MH  - Glyburide
MH  - Indomethacin/*toxicity
MH  - Male
MH  - NG-Nitroarginine Methyl Ester
MH  - Pyrazoles
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stomach Ulcer/*chemically induced/prevention & control
EDAT- 2015/10/27 06:00
MHDA- 2016/10/25 06:00
CRDT- 2015/10/27 06:00
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
AID - 10.1039/c5fo00403a [doi]
PST - ppublish
SO  - Food Funct. 2016 Jan;7(1):398-408. doi: 10.1039/c5fo00403a.