PMID- 26499924
OWN - NLM
STAT- MEDLINE
DCOM- 20161101
LR  - 20161230
IS  - 1542-7714 (Electronic)
IS  - 1542-3565 (Linking)
VI  - 14
IP  - 2
DP  - 2016 Feb
TI  - Low Prevalence of Hypomagnesemia in Long-term Recipients of Proton Pump 
      Inhibitors in a Managed Care Cohort.
PG  - 317-21
LID - S1542-3565(15)01408-1 [pii]
LID - 10.1016/j.cgh.2015.10.012 [doi]
AB  - BACKGROUND & AIMS: Chronic intake of proton pump inhibitors (PPI) has been 
      associated with hypomagnesemia, but prevalence of PPI-associated hypomagnesemia 
      is not known. METHODS: We examined the prevalence of hypomagnesemia among 
      long-term PPI recipients by using a large health maintenance organization 
      database. We collected data on 10,167 participants eligible for chronic drug 
      prescriptions from 2008 through 2013. Adult subjects receiving continuous PPI 
      therapy for >/= 6 months between 2008 and 2013 and >/= 1 serum magnesium 
      determination(s) were identified. Patients with any magnesium levels less than 
      1.6 mg/dL were selected for analysis; those with recognizable causes of altered 
      magnesium homeostasis were excluded. RESULTS: Five hundred ninety participants 
      received long-term PPIs, and 414 (70.2%) met the inclusion criteria for a total 
      exposure of 2293 PPI-years (average, 5.7 years/subject). Of these patients, 57 
      (13.8%) had >/= 1 low serum magnesium; 5 were no longer on PPIs, and 44 had other 
      recognizable causes for hypomagnesemia (25 receiving diuretics, 8 with chronic 
      diarrhea, 8 with chronic kidney disease, and 3 with malignancies). Of the 8 
      remaining patients (7 female; mean age, 71.2 +/- 13.4 years; mean daily 
      medications, 5.4 +/- 1.1), mild hypomagnesemia (range, 1.2-1.5 mg/dL) was noted in 
      13.9% of 289 measurements. All 8 patients had normal serum levels of magnesium at 
      their final measurement. CONCLUSIONS: In the absence of known precipitating 
      factors, chronic PPI use does not appear to be associated with hypomagnesemia.
CI  - Copyright (c) 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.
FAU - Sharara, Ala I
AU  - Sharara AI
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon. Electronic address: 
      ala.sharara@aub.edu.lb.
FAU - Chalhoub, Jean M
AU  - Chalhoub JM
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Hammoud, Nijmeh
AU  - Hammoud N
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Harb, Ali H
AU  - Harb AH
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Sarkis, Fayez S
AU  - Sarkis FS
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Hamadeh, Ghassan
AU  - Hamadeh G
AD  - Department of Family Medicine, American University of Beirut Medical Center, 
      Beirut, Lebanon.
LA  - eng
PT  - Journal Article
DEP - 20151020
PL  - United States
TA  - Clin Gastroenterol Hepatol
JT  - Clinical gastroenterology and hepatology : the official clinical practice journal 
      of the American Gastroenterological Association
JID - 101160775
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Magnesium Deficiency/*chemically induced/*epidemiology
MH  - Male
MH  - Managed Care Programs
MH  - Middle Aged
MH  - Prevalence
MH  - Proton Pump Inhibitors/*adverse effects/*therapeutic use
OTO - NOTNLM
OT  - Acid Suppression
OT  - Adverse Events
OT  - Diuretics
OT  - Magnesium
OT  - Side Effects
EDAT- 2015/10/27 06:00
MHDA- 2016/11/02 06:00
CRDT- 2015/10/27 06:00
PHST- 2015/06/27 00:00 [received]
PHST- 2015/10/06 00:00 [revised]
PHST- 2015/10/07 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/11/02 06:00 [medline]
AID - S1542-3565(15)01408-1 [pii]
AID - 10.1016/j.cgh.2015.10.012 [doi]
PST - ppublish
SO  - Clin Gastroenterol Hepatol. 2016 Feb;14(2):317-21. doi: 
      10.1016/j.cgh.2015.10.012. Epub 2015 Oct 20.