PMID- 26500934
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151027
LR  - 20201001
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 9
IP  - 9
DP  - 2015 Sep
TI  - Decreased Bone Mineral Density at the Femoral Neck and Lumbar Spine in South 
      Indian Patients with Type 2 Diabetes.
PG  - OC08-12
LID - 10.7860/JCDR/2015/14390.6450 [doi]
AB  - BACKGROUND: With prevalence of diabetes in India reaching epidemic proportions 
      and increase in the population of geriatric age group and risks of falls, it is 
      important to understand the effect that diabetes has on bone health. AIM: The 
      objective was to assess bone mineral density (BMD) of patients with type 2 
      diabetes mellitus (T2DM) and to study factors contributing to BMD in patients 
      with T2DM. MATERIALS AND METHODS: This was a prospective cross-sectional study on 
      150 patients with T2DM (diagnosed at age > 30 years) and an equal number (n=150) 
      of age and sex matched healthy controls from September 2012 to July 2014 at a 
      tertiary care center located in Southern India. BMD was measured at the femoral 
      neck and lumbar spine (L2-L4) by dual energy absorptiometry (DXA) in cases and 
      controls. Serum total calcium, phosphorus and alkaline phosphatase (ALP) and 
      25-OH- vitamin D3 was measured in patient group. RESULTS: Mean age (SD) was 51.29 
      (+/-8.05) and 51 (+/-8.3) years in cases and controls, respectively. The femoral neck 
      and lumbar spine BMD was significantly lower in T2DM cases compared to controls. 
      Also the femoral neck and lumbar spine T-score was significantly lower in T2DM 
      cases compared to controls. Femoral neck BMD among male patients with T2DM was 
      significantly lower compared to controls (men). Among women, BMD at femoral neck 
      as well as lumbar spine was significantly lower in cases when compared to 
      controls. Ninety six out of 150 (64%) T2DM cases had Vitamin D values <20 ng/mL. 
      There was weak negative correlation between age of patient, duration of diabetes 
      and HbA1C with femoral neck BMD. There was weak negative correlation between 
      HbA1C and lumbar spine BMD. CONCLUSION: Indian subjects with type 2 diabetes have 
      significantly lower BMD at both femoral neck and lumbar spine compared to age and 
      sex matched healthy controls. We conclude that osteopenia and osteoporosis are 
      overlooked complications of diabetes. Longitudinal studies are needed to see for 
      actual incidence of fractures among this high risk group.
FAU - Mathen, Pratheesh George
AU  - Mathen PG
AD  - Junior Resident, Department of Medicine JIPMER , Puducherry, India .
FAU - Thabah, Molly Mary
AU  - Thabah MM
AD  - Associate Professor, Department of Medicine, JIPMER , Puducherry, India .
FAU - Zachariah, Bobby
AU  - Zachariah B
AD  - Professor and Head, Department of Biochemistry, JIPMER , Puducherry, India .
FAU - Das, Ashok Kumar
AU  - Das AK
AD  - Senior Professor, Department of Medicine, JIPMER , Puducherry, India .
LA  - eng
PT  - Journal Article
DEP - 20150901
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC4606263
OTO - NOTNLM
OT  - BMD
OT  - Fractures
OT  - Osteoporosis
OT  - Vitamin D deficiency
EDAT- 2015/10/27 06:00
MHDA- 2015/10/27 06:01
PMCR- 2015/11/01
CRDT- 2015/10/27 06:00
PHST- 2015/04/08 00:00 [received]
PHST- 2015/07/15 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2015/10/27 06:01 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2015/14390.6450 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2015 Sep;9(9):OC08-12. doi: 10.7860/JCDR/2015/14390.6450. Epub 
      2015 Sep 1.