PMID- 26501066
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2329-6488 (Print)
IS  - 2329-6488 (Electronic)
IS  - 2329-6488 (Linking)
VI  - 2
IP  - 2
DP  - 2014 May
TI  - Mood Disorders and BDNF Relationship with Alcohol Drinking Trajectories among 
      PLWH Receiving Care.
PG  - 148
AB  - BACKGROUND: Despite the excessive rates of Hazardous Alcohol Use (HAU) among 
      people living with HIV (PLWH), although largely speculated, psychological and 
      physiological components associated with HAU, has not been actively measured. 
      Therefore, the present study was geared toward determining: 1) the rates of mood 
      disorders and its relationship with HAU, and 2) to assess the impact of Brain 
      Derived Neurotrophic Factor (BDNF), a well-known regulator of alcohol and mood 
      disorders. METHODS: For this study, participants of the longitudinal PADS Study 
      n=400, were followed over time. Alcohol use (Alcohol Use Disorders Identification 
      Test -AUDIT- and the Alcohol Dependence Scale -ADS) and moods (depression, 
      anxiety, and stress) were assessed repeatedly. RESULTS: A cluster analyses shows 
      three distinctive trajectories. The first one, revealed a group with increased 
      drinking (Cluster 1: n=140), constant alcohol intake (Cluster 2: n = 60), and one 
      with decreased consumption (Cluster 3: n =120). Analyses discovered higher AUDIT 
      scores across the clusters with Cluster 1 being followed by Clusters 2 and 3 (1: 
      14.5 +/- 8 vs. 2=8.7 +/- 7.5 vs. 3= 6.6 +/- 4.2, p = 0.001). Women in Clusters 1 and 2 
      had higher levels of stress (1:21 +/- 7.5; 2:19.3 +/- 7) and lower BDNF levels (7904 
      +/- 1248 pg/ml and 10405 +/- 909 pg/mL) than their counterparts in Cluster 3 (PSS: 3: 
      16.6 +/-5, p = 0.02 BDNF: 10828 +/- 1127 pg/mL, p = 0.08). Men in Cluster 1 differed 
      in terms of stress (19.8 +/- 7 vs. 21 +/- 7.5 score) and BDNF levels (Cluster 1: 5204 
      +/- 818 vs. Cluster 2: 7656 +/- 843 pg/ml, p = 0.002) but not in the number of years 
      living with HIV. The proportion of subjects with multiple mood comorbidities was 
      disturbingly higher (26%), and all were members of Cluster 1. Multiple logistic 
      regression analyses indicated that participants reporting high relative to low 
      levels of perceived stress, dual mood comorbidity, altered BDNF levels and low 
      income increased the likelihood of being a member of Cluster 1. CONCLUSION: This 
      study found that stress and overlaying psychiatric comorbidities are linked with 
      persistent alcohol use. Findings suggest that BDNF and social support seems to be 
      a logical target as it seems to be the bridge linking mood disorders and alcohol 
      consumption.
FAU - Miguez-Burbano, Maria Jose
AU  - Miguez-Burbano MJ
AD  - School of Integrated Science and Humanity, Florida International University, 
      Miami, FL, USA.
FAU - Espinoza, Luis
AU  - Espinoza L
AD  - Department of Medicine, University of Miami School of Medicine, Miami, FL, USA.
FAU - Vargas, Mayra
AU  - Vargas M
AD  - School of Integrated Science and Humanity, Florida International University, 
      Miami, FL, USA.
FAU - LaForest, Diana
AU  - LaForest D
AD  - School of Integrated Science and Humanity, Florida International University, 
      Miami, FL, USA.
LA  - eng
GR  - U24 AA022002/AA/NIAAA NIH HHS/United States
GR  - R21 AA013793/AA/NIAAA NIH HHS/United States
GR  - R01 DA014218/DA/NIDA NIH HHS/United States
GR  - R01 AA018095/AA/NIAAA NIH HHS/United States
GR  - R01 DA015628/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20140210
PL  - United States
TA  - J Alcohol Drug Depend
JT  - Journal of alcoholism and drug dependence
JID - 101608872
PMC - PMC4612491
MID - NIHMS706248
OTO - NOTNLM
OT  - Alcohol trajectories
OT  - Anxiety
OT  - BDNF
OT  - Depression
OT  - Gender
OT  - HIV
OT  - Hazardous alcohol
OT  - Mood
OT  - Stress
COIS- Conflict of Interest Statement The author(s) report(s) no real or perceived 
      vested interests that relate to this article that could be construed as a 
      conflict of interest.
EDAT- 2014/05/01 00:00
MHDA- 2014/05/01 00:01
PMCR- 2015/10/21
CRDT- 2015/10/27 06:00
PHST- 2015/10/27 06:00 [entrez]
PHST- 2014/05/01 00:00 [pubmed]
PHST- 2014/05/01 00:01 [medline]
PHST- 2015/10/21 00:00 [pmc-release]
AID - 10.4172/2329-6488.1000148 [doi]
PST - ppublish
SO  - J Alcohol Drug Depend. 2014 May;2(2):148. doi: 10.4172/2329-6488.1000148. Epub 
      2014 Feb 10.