PMID- 26501189
OWN - NLM
STAT- MEDLINE
DCOM- 20160824
LR  - 20221115
IS  - 1528-8951 (Electronic)
IS  - 0148-0731 (Print)
IS  - 0148-0731 (Linking)
VI  - 138
IP  - 1
DP  - 2016 Jan
TI  - Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen 
      Electrospun Scaffolds to Porcine Coronary Arteries.
PG  - 0110011-01100112
LID - 10.1115/1.4031847 [doi]
AB  - Cardiovascular disease (CVD) is the leading cause of death for Americans. As 
      coronary artery bypass graft surgery (CABG) remains a mainstay of therapy for CVD 
      and native vein grafts are limited by issues of supply and lifespan, an effective 
      readily available tissue-engineered vascular graft (TEVG) for use in CABG would 
      provide drastic improvements in patient care. Biomechanical mismatch between 
      vascular grafts and native vasculature has been shown to be the major cause of 
      graft failure, and therefore, there is need for compliance-matched biocompatible 
      TEVGs for clinical implantation. The current study investigates the biaxial 
      mechanical characterization of acellular electrospun glutaraldehyde (GLUT) 
      vapor-crosslinked gelatin/fibrinogen cylindrical constructs, using a custom-made 
      microbiaxial optomechanical device (MOD). Constructs crosslinked for 2, 8, and 
      24 hrs are compared to mechanically characterized porcine left anterior 
      descending coronary (LADC) artery. The mechanical response data were used for 
      constitutive modeling using a modified Fung strain energy equation. The results 
      showed that constructs crosslinked for 2 and 8 hrs exhibited circumferential and 
      axial tangential moduli (ATM) similar to that of the LADC. Furthermore, the 8-hrs 
      experimental group was the only one to compliance-match the LADC, with compliance 
      values of 0.0006+/-0.00018 mm Hg-1 and 0.00071+/-0.00027 mm Hg-1, respectively. The 
      results of this study show the feasibility of meeting mechanical specifications 
      expected of native arteries through manipulating GLUT vapor crosslinking time. 
      The comprehensive mechanical characterization of cylindrical biopolymer 
      constructs in this study is an important first step to successfully develop a 
      biopolymer compliance-matched TEVG.
FAU - Tamimi, E
AU  - Tamimi E
FAU - Ardila, D C
AU  - Ardila DC
FAU - Haskett, D G
AU  - Haskett DG
FAU - Doetschman, T
AU  - Doetschman T
FAU - Slepian, M J
AU  - Slepian MJ
FAU - Kellar, R S
AU  - Kellar RS
FAU - Vande Geest, J P
AU  - Vande Geest JP
LA  - eng
GR  - S10RR023737/RR/NCRR NIH HHS/United States
GR  - S10 RR023737/RR/NCRR NIH HHS/United States
GR  - R21 HL111990/HL/NHLBI NIH HHS/United States
GR  - 1R21HL111990-01A1/HL/NHLBI NIH HHS/United States
GR  - T32 HL007955/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Biomech Eng
JT  - Journal of biomechanical engineering
JID - 7909584
RN  - 9000-70-8 (Gelatin)
RN  - 9001-32-5 (Fibrinogen)
RN  - T3C89M417N (Glutaral)
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Coronary Vessels/*cytology
MH  - *Electricity
MH  - Fibrinogen/*chemistry
MH  - Gelatin/*chemistry
MH  - Glutaral/*chemistry
MH  - Materials Testing
MH  - *Mechanical Phenomena
MH  - Pressure
MH  - Stress, Mechanical
MH  - Swine
MH  - Tissue Scaffolds/*chemistry
PMC - PMC4844094
EDAT- 2015/10/27 06:00
MHDA- 2016/08/25 06:00
PMCR- 2017/01/01
CRDT- 2015/10/27 06:00
PHST- 2015/03/30 00:00 [received]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/08/25 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 2466198 [pii]
AID - BIO-15-1133 [pii]
AID - 10.1115/1.4031847 [doi]
PST - ppublish
SO  - J Biomech Eng. 2016 Jan;138(1):0110011-01100112. doi: 10.1115/1.4031847.