PMID- 26502747
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20170328
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 69
IP  - 6
DP  - 2016 Jun
TI  - Nodular pulmonary light chain deposition disease: an entity associated with 
      Sjogren syndrome or marginal zone lymphoma.
PG  - 490-6
LID - 10.1136/jclinpath-2015-203342 [doi]
AB  - BACKGROUND: Light chain deposition disease (LCDD) is usually a systemic disorder 
      characterised by non-amyloid monoclonal immunoglobulin light chain deposition in 
      tissues. Localised nodular pulmonary (NP) LCDD is a rare and poorly characterised 
      entity and, owing to the difficulties in diagnosis, limited data are available. 
      METHODS: We investigated the clinical, radiological and pathological 
      characteristics of a series of six confidently diagnosed cases of NPLCDD. 
      RESULTS: There were three men and three women with ages ranging from 33 to 
      74 years. In all cases there were single or multiple pulmonary nodules, in one 
      case associated with cysts. Two patients had no previous history of a 
      lymphoproliferative or autoimmune disorder, two had Sjogren syndrome (SS) and two 
      had extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT 
      lymphoma). Lung biopsies led to diagnoses of MALT lymphoma in four patients, 
      including both of those with a previous history of lymphoma and one with SS. In 
      five cases the diagnosis was confirmed by liquid chromatography-tandem mass 
      spectrometry (LC-MS/MS) and in one by electron microscopy. There was no evidence 
      of systemic LCDD in any of the cases. Five patients had an indolent course in 
      spite of limited therapeutic intervention while, in the patient who died, the 
      cause of death was related to the spread of the lymphoma and was not due to the 
      pulmonary lesions. CONCLUSIONS: NPLCDD is an indolent disease, in most cases 
      associated with MALT lymphoma or autoimmune disease.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/
FAU - Arrossi, A V
AU  - Arrossi AV
AD  - R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
FAU - Merzianu, M
AU  - Merzianu M
AD  - Departement of Pathology, Roswell Park Cancer Institute, Buffalo, New York, USA.
FAU - Farver, C
AU  - Farver C
AD  - R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
FAU - Yuan, C
AU  - Yuan C
AD  - R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
FAU - Wang, S H
AU  - Wang SH
AD  - R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
FAU - Nakashima, M O
AU  - Nakashima MO
AD  - R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
FAU - Cotta, C V
AU  - Cotta CV
AD  - R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20151026
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
RN  - 0 (Immunoglobulin Light Chains)
RN  - Familial primary gastric lymphoma
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Lung/*pathology
MH  - Lymphoma, B-Cell, Marginal Zone/diagnostic imaging/*genetics
MH  - Lymphoma, Non-Hodgkin/diagnostic imaging/*genetics
MH  - Male
MH  - Middle Aged
MH  - Paraproteinemias
MH  - Sjogren's Syndrome/diagnostic imaging/*genetics
MH  - Stomach Neoplasms/diagnostic imaging/*genetics
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - IMMUNOGLOBULIN
OT  - LYMPHOMA
OT  - PULMONARY PATHOLOGY
EDAT- 2015/10/28 06:00
MHDA- 2017/03/30 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/08/17 00:00 [received]
PHST- 2015/10/03 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
AID - jclinpath-2015-203342 [pii]
AID - 10.1136/jclinpath-2015-203342 [doi]
PST - ppublish
SO  - J Clin Pathol. 2016 Jun;69(6):490-6. doi: 10.1136/jclinpath-2015-203342. Epub 
      2015 Oct 26.