PMID- 26503351
OWN - NLM
STAT- MEDLINE
DCOM- 20160314
LR  - 20210421
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 63
IP  - 11
DP  - 2015 Nov
TI  - Newly Developed Chronic Conditions and Changes in Health-Related Quality of Life 
      in Postmenopausal Women.
PG  - 2349-57
LID - 10.1111/jgs.13796 [doi]
AB  - OBJECTIVES: To prospectively assess the effects of newly developed chronic 
      conditions on changes in health-related quality of life (HRQoL) in postmenopausal 
      women. DESIGN: Prospective cohort study. SETTING: Forty clinical centers in the 
      United States. PARTICIPANTS: Women aged 50 to 79 enrolled in the Women's Health 
      Initiative Observational Study during 1993-98 (N = 75,198). MEASUREMENTS: Onset 
      of seven chronic conditions (hypertension, heart disease, stroke, cancer, 
      osteoporosis, diabetes mellitus, arthritis), HRQoL based on the Medical Outcomes 
      Study 36-item Short Form survey (SF-36), and change in HRQoL from baseline to 
      Year 3 in scores on the Physical (PCS) and Mental (MCS) Component Summary of the 
      SF-36. RESULTS: Each of the seven chronic conditions was statistically 
      significantly associated with HRQoL for physical and mental health. Women with 
      incident stroke had the greatest decline in HRQoL for physical and mental health 
      (PCS: 10.2, 95% confidence interval (CI) = 8.3-12.1; MCS: 10.4, 95% CI = 
      8.8-12.1), which exceeded minimal clinically important differences (MCID). Having 
      more new chronic conditions was associated with greater decrease in HRQoL. 
      Declines in HRQoL in women with two or more chronic conditions exceeded MCID. 
      Those with heart disease and stroke had the largest decline in physical health, 
      and those with stroke and arthritis had the greatest decline in mental health. 
      For all conditions other than stroke and diabetes mellitus, the more recently a 
      condition was diagnosed, the greater the decrease in PCS. For stroke and cancer, 
      a similar pattern was observed for MCS. CONCLUSION: The more conditions a woman 
      developed, the greater reduction in HRQoL she experienced. Declines in HRQoL in 
      women with stroke, cancer, and some combinations exceeded MCID. Findings from 
      this study might lead to more-effective patient-centered approaches to health 
      care for women with multiple chronic conditions.
CI  - (c) 2015, Copyright the Authors Journal compilation (c) 2015, The American Geriatrics 
      Society.
FAU - Luo, Juhua
AU  - Luo J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Indiana 
      University, Bloomington, Indiana.
FAU - Hendryx, Michael
AU  - Hendryx M
AD  - Department of Applied Health Science, School of Public Health, Indiana 
      University, Bloomington, Indiana.
FAU - Safford, Monika M
AU  - Safford MM
AD  - Division of Preventive Medicine, Department of Medicine, University of Alabama at 
      Birmingham, Birmingham, Alabama.
FAU - Wallace, Robert
AU  - Wallace R
AD  - Department of Epidemiology, College of Public Health, University of Iowa, Iowa 
      City, Iowa.
FAU - Rossom, Rebecca
AU  - Rossom R
AD  - HealthPartners Institute for Education and Research, Minneapolis, Minnesota.
FAU - Eaton, Charles
AU  - Eaton C
AD  - Department of Family Medicine, Alpert Medical School, Brown University, 
      Providence, Rhode Island.
AD  - Department of Epidemiology, School of Public Health, Brown University, 
      Providence, Rhode Island.
AD  - Family Care Center, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island.
FAU - Bassuk, Shari
AU  - Bassuk S
AD  - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, 
      Massachusetts.
FAU - Margolis, Karen L
AU  - Margolis KL
AD  - HealthPartners Institute for Education and Research, Minneapolis, Minnesota.
LA  - eng
GR  - HHSN268201100001C/WH/WHI NIH HHS/United States
GR  - HHSN271201100004C/AG/NIA NIH HHS/United States
GR  - HHSN268201100004C/WH/WHI NIH HHS/United States
GR  - HHSN268201100002C/WH/WHI NIH HHS/United States
GR  - HHSN268201100046C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100003C/WH/WHI NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
DEP - 20151027
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Aged
MH  - Arthritis/etiology
MH  - Cardiovascular Diseases/etiology
MH  - *Chronic Disease
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/etiology
MH  - Female
MH  - Humans
MH  - Hypertension/*etiology
MH  - Middle Aged
MH  - Neoplasms/etiology
MH  - Osteoporosis/etiology
MH  - Postmenopause/*psychology
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Stroke/etiology
OTO - NOTNLM
OT  - chronic conditions
OT  - health-related quality of life
OT  - postmenopausal women
EDAT- 2015/10/28 06:00
MHDA- 2016/03/15 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/03/15 06:00 [medline]
AID - 10.1111/jgs.13796 [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2015 Nov;63(11):2349-57. doi: 10.1111/jgs.13796. Epub 2015 Oct 
      27.