PMID- 26503495
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20221207
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Linking)
VI  - 27
IP  - 6
DP  - 2015 Dec
TI  - Meta-analysis of the association of brain-derived neurotrophic factor Val66Met 
      polymorphism with obsessive-compulsive disorder.
PG  - 327-35
LID - 10.1017/neu.2015.38 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays an important role in 
      neural survival and was proposed to be related to psychiatric disorders. Val66Met 
      (also known as rs6265 or G196A), the only known functional polymorphism of the 
      BDNF gene, has been widely studied and considered to be associated with risk of 
      some psychiatric disorders such as bipolar disorder and schizophrenia. However, 
      studies evaluating its association with obsessive-compulsive disorder (OCD) 
      obtained inconsistent results. The purpose of this study was to derive a more 
      precise estimation of the association between BDNF Val66Met polymorphism and OCD 
      susceptibility by a meta-analysis. METHOD: We carried a structured literature 
      search in PubMed, Embase, PsycINFO and Chinese Biomedical Database up to December 
      2014; and retrieved all eligible case-control studies according to the including 
      criteria. Meta-analysis was performed for four genetic models: allelic model: Met 
      versus Val; additive model: Met/Met versus Val/Val; recessive model: Met/Met 
      versus Val/Val+Val/Met; and dominant model: Val/Met+Met/Met versus Val/Val. 
      Stratified analyses were performed by ethnicity and gender where appropriate. 
      RESULTS: A total of eight articles with nine studies including 1632 OCD cases and 
      2417 controls were identified. No significant association was detected in any 
      comparison when the whole data were pooled together or stratified by ethnicity or 
      gender in all four genetic models (p>0.05 for each comparison). CONCLUSION: 
      Despite some limitations, our meta-analysis suggests that no significant 
      association exists between the BDNF Val66Met polymorphism and OCD susceptibility.
FAU - Wang, Jun
AU  - Wang J
AD  - 1Department of Clinical Psychiatry,Wuxi Mental Health Center,Nanjing Medical 
      University,Wuxi,Jiangsu Province,China.
FAU - Zhang, Fuquan
AU  - Zhang F
AD  - 2Department of Clinical Psychology,Wuxi Mental Health Center,Nanjing Medical 
      University,Wuxi,Jiangsu Province,China.
FAU - Zhu, Wenxian
AU  - Zhu W
AD  - 1Department of Clinical Psychiatry,Wuxi Mental Health Center,Nanjing Medical 
      University,Wuxi,Jiangsu Province,China.
FAU - Liu, Yansong
AU  - Liu Y
AD  - 2Department of Clinical Psychology,Wuxi Mental Health Center,Nanjing Medical 
      University,Wuxi,Jiangsu Province,China.
FAU - Zhou, Zhenhe
AU  - Zhou Z
AD  - 1Department of Clinical Psychiatry,Wuxi Mental Health Center,Nanjing Medical 
      University,Wuxi,Jiangsu Province,China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Obsessive-Compulsive Disorder/*genetics/metabolism
MH  - *Polymorphism, Single Nucleotide
MH  - White People/genetics
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - meta-analysis
OT  - obsessive-compulsive disorder
OT  - polymorphism
EDAT- 2015/10/28 06:00
MHDA- 2016/06/21 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
AID - S0924270815000381 [pii]
AID - 10.1017/neu.2015.38 [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2015 Dec;27(6):327-35. doi: 10.1017/neu.2015.38.