PMID- 26503595
OWN - NLM
STAT- MEDLINE
DCOM- 20161226
LR  - 20181202
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 134
IP  - 2
DP  - 2016 Aug
TI  - Association between subclinical carotid atherosclerosis, hyperhomocysteinaemia 
      and mild cognitive impairment.
PG  - 154-9
LID - 10.1111/ane.12525 [doi]
AB  - OBJECTIVE: Evidence suggests that intima-media thickness (IMT) and plasma 
      homocysteine (Hcy) levels are associated with one another, and both appear to be 
      related to cognitive dysfunction. However, no connection between both factors 
      taken together and mild cognitive impairment (MCI) has been established. This 
      study analysed potential relationships between IMT, Hcy and MCI. METHODS: We 
      included 105 patients with MCI and 76 controls with no history of vascular 
      disease. All participants underwent laboratory analyses, a carotid ultrasound, 
      and clinical and neuropsychological assessment. We used the Mantel-Haenszel test 
      (MHT), ANCOVA and multiple linear regression models (MLRM) to examine any 
      associations between IMT, Hcy and cognitive state. RESULTS: The MHT revealed a 
      significant association between IMT and risk of MCI (z = 4.285, P < 0.0001). The 
      OR for the upper quartile vs the lower quartile was 5.12 (95% CI: 2.12-12.36). 
      MHT also showed a clear association between Hcy levels and risk of MCI (z = 3.01, 
      P = 0.003). OR for the upper vs the lower quartile was 3.39 (95% CI: 1.41-8.12). 
      Additionally, we found a correlation between IMT and Hcy (r = 0.162, P = 0.032). 
      CONCLUSIONS: Our results suggest that there is a connection between IMT, Hcy 
      levels and presence of amnestic MCI in a population with no history of clinically 
      manifest atherosclerosis. Furthermore, there is also a connection between the IMT 
      and Hcy levels themselves.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Casado-Naranjo, I
AU  - Casado-Naranjo I
AD  - Department of Neurology, Hospital San Pedro de Alcantara, Caceres, Spain.
AD  - CIBERNED, Department of Biochemistry and Molecular Biology and Genetics, Nursing 
      College, Universidad de Extremadura, Caceres, Spain.
FAU - Romero Sevilla, R
AU  - Romero Sevilla R
AD  - Department of Neurology, Hospital San Pedro de Alcantara, Caceres, Spain.
FAU - Portilla Cuenca, J C
AU  - Portilla Cuenca JC
AD  - Department of Neurology, Hospital San Pedro de Alcantara, Caceres, Spain.
FAU - Duque de San Juan, B
AU  - Duque de San Juan B
AD  - Department of Neurology, Hospital San Pedro de Alcantara, Caceres, Spain.
FAU - Calle Escobar, M L
AU  - Calle Escobar ML
AD  - Department of Neurology, Hospital San Pedro de Alcantara, Caceres, Spain.
FAU - Fernandez Pereira, L
AU  - Fernandez Pereira L
AD  - Department of Immunology, Hospital San Pedro de Alcantara, Caceres, Spain.
FAU - Fuentes, J M
AU  - Fuentes JM
AD  - CIBERNED, Department of Biochemistry and Molecular Biology and Genetics, Nursing 
      College, Universidad de Extremadura, Caceres, Spain.
FAU - Ramirez-Moreno, J M
AU  - Ramirez-Moreno JM
AD  - Department of Neurology, Hospital Universitario Infanta Cristina, Badajoz, Spain.
LA  - eng
PT  - Journal Article
DEP - 20151027
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carotid Artery Diseases/*epidemiology/pathology
MH  - *Carotid Intima-Media Thickness
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/blood/*epidemiology/pathology
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - atherosclerosis
OT  - homocysteine
OT  - intima-media thickness
OT  - mild cognitive impairment
EDAT- 2015/10/28 06:00
MHDA- 2016/12/27 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/09/29 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/12/27 06:00 [medline]
AID - 10.1111/ane.12525 [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2016 Aug;134(2):154-9. doi: 10.1111/ane.12525. Epub 2015 Oct 
      27.