PMID- 26503747
OWN - NLM
STAT- MEDLINE
DCOM- 20161219
LR  - 20161230
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 46
IP  - 4
DP  - 2016 Apr
TI  - The dendritic cell high-affinity IgE receptor is overexpressed in both asthma and 
      severe COPD.
PG  - 575-83
LID - 10.1111/cea.12664 [doi]
AB  - BACKGROUND: The reduction of asthma exacerbations following omalizumab treatment 
      has been related to the suppression of the high-affinity IgE receptor (FcepsilonRI) on 
      plasmacytoid dendritic cells (DCs). However, the FcepsilonRI expression on DCs in 
      chronic obstructive pulmonary disease (COPD) is unknown. OBJECTIVE: To compare 
      FcepsilonRI expression on DCs in COPD with patients with allergic asthma and healthy 
      controls, and to relate the findings to clinical parameters, blood eosinophil 
      concentrations and serum immunoglobin E (IgE) concentrations. METHODS: Using 
      four-colour flow cytometry, FcepsilonRI expression on blood myeloid DCs and 
      plasmacytoid DCs was analyzed in 64 patients with COPD, 20 patients with allergic 
      asthma, 41 asymptomatic never smokers and 21 asymptomatic current smokers. 
      RESULTS: As compared with never smokers, current smokers displayed an increased 
      expression of the FcepsilonRI on myeloid and plasmacytoid DCs. In patients with COPD, 
      the expression of the FcepsilonRI on plasmacytoid DCs, but not myeloid DCs, increased 
      from spirometric GOLD stage 2 to GOLD stage 4, and was correlated with several 
      lung function parameters. Patients with severe COPD and patients with allergic 
      asthma displayed a similar FcepsilonRI overexpression on plasmacytoid DCs. In all 
      groups, there was a positive correlation between total IgE serum concentrations 
      and the FcepsilonRI expression on plasmacytoid DCs. CONCLUSIONS AND CLINICAL RELEVANCE: 
      Severe COPD and allergic asthma are characterized by a similar overexpression of 
      the high-affinity IgE receptor on plasmacytoid DCs. In view of the effect of 
      anti-IgE on exacerbations in asthma, trials investigating the effect of anti-IgE 
      on exacerbations in severe COPD appear to be warranted.
CI  - (c) 2015 John Wiley & Sons Ltd.
FAU - Stoll, P
AU  - Stoll P
AD  - Department of Pneumology and Critical Care Medicine, University of Rostock, 
      Rostock, Germany.
FAU - Bahker, A
AU  - Bahker A
AD  - Department of Pneumology and Critical Care Medicine, University of Rostock, 
      Rostock, Germany.
FAU - Ulrich, M
AU  - Ulrich M
AD  - Department of Pneumology and Critical Care Medicine, University of Rostock, 
      Rostock, Germany.
FAU - Bratke, K
AU  - Bratke K
AD  - Department of Pneumology and Critical Care Medicine, University of Rostock, 
      Rostock, Germany.
FAU - Garbe, K
AU  - Garbe K
AD  - Department of Pneumology and Critical Care Medicine, University of Rostock, 
      Rostock, Germany.
FAU - Christian Virchow, J
AU  - Christian Virchow J
AD  - Department of Pneumology and Critical Care Medicine, University of Rostock, 
      Rostock, Germany.
FAU - Lommatzsch, M
AU  - Lommatzsch M
AD  - Department of Pneumology and Critical Care Medicine, University of Rostock, 
      Rostock, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asthma/diagnosis/*immunology/*metabolism
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Eosinophils
MH  - Female
MH  - Flow Cytometry
MH  - Gene Expression
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Immunophenotyping
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/diagnosis/*immunology/*metabolism
MH  - Receptors, IgE/genetics/*metabolism
MH  - Respiratory Function Tests
MH  - Risk Factors
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - COPD
OT  - asthma
OT  - dendritic cell
OT  - flow cytometry
OT  - immunoglobulin E
EDAT- 2015/10/28 06:00
MHDA- 2016/12/20 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/07/21 00:00 [received]
PHST- 2015/08/31 00:00 [revised]
PHST- 2015/10/12 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/12/20 06:00 [medline]
AID - 10.1111/cea.12664 [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2016 Apr;46(4):575-83. doi: 10.1111/cea.12664.