PMID- 26504179
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20170512
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 100
IP  - 7
DP  - 2016 Jul
TI  - Correlation between peripapillary retinal thickness and serum level of vascular 
      endothelial growth factor in patients with POEMS syndrome.
PG  - 897-901
LID - 10.1136/bjophthalmol-2015-307068 [doi]
AB  - AIMS: To determine whether there is a significant correlation between the 
      peripapillary retinal thickness (pRT) and the serum level of vascular endothelial 
      growth factor (VEGF) in patients with polyneuropathy, organomegaly, 
      endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome. METHODS: 
      This was a cross-sectional, observational case series. We studied 34 eyes of 17 
      treatment-naive patients with POEMS syndrome whose intracranial pressure was 
      within the normal range. The spectral-domain optical coherence tomographic 
      (SD-OCT) examinations consisted of circle scans of 3.45 mm diameter around the 
      optic disc. The pRT was automatically measured in the SD-OCT images and was used 
      for the statistical analysis. The serum level of VEGF was measured by ELISAs, and 
      the correlation between the pRT and the serum level of VEGF was determined. 
      Multivariable logistic regression analyses were used to identify independent 
      factors that were correlated with the pRT. RESULTS: There was a significant 
      positive correlation between the serum levels of VEGF and the average pRT of the 
      two eyes of each patient (r=0.81, p<0.0001). There was a significant correlation 
      between the pRT of the right and left eyes with an intraclass correlation 
      coefficient of 0.839. Multiple regression analysis showed that the serum levels 
      of VEGF were independent contributors to the pRT (standard regression 
      coefficient=0.59, p=0.012). CONCLUSIONS: The significant correlation between the 
      pRT and the serum level of VEGF suggests that the higher serum level of VEGF 
      might be associated with the development of the optic disc oedema in patients 
      with POEMS syndrome.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Yokouchi, Hirotaka
AU  - Yokouchi H
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Chiba University, Chiba, Japan.
FAU - Baba, Takayuki
AU  - Baba T
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Chiba University, Chiba, Japan.
FAU - Misawa, Sonoko
AU  - Misawa S
AD  - Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, 
      Japan.
FAU - Sawai, Setsu
AU  - Sawai S
AD  - Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, 
      Japan.
AD  - Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 
      Chiba, Japan.
AD  - Division of Laboratory Medicine and Clinical Genetics, Chiba University Hospital, 
      Chiba, Japan.
FAU - Kitahashi, Masayasu
AU  - Kitahashi M
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Chiba University, Chiba, Japan.
FAU - Oshitari, Toshiyuki
AU  - Oshitari T
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Chiba University, Chiba, Japan.
FAU - Kuwabara, Satoshi
AU  - Kuwabara S
AD  - Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, 
      Japan.
FAU - Yamamoto, Shuichi
AU  - Yamamoto S
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Chiba University, Chiba, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20151026
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - 0 (Biomarkers)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Intracranial Pressure
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*diagnostic imaging
MH  - POEMS Syndrome/blood/complications/*diagnosis
MH  - Papilledema/blood/diagnosis/*etiology
MH  - Prognosis
MH  - Retina/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2015/10/28 06:00
MHDA- 2017/05/13 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/04/23 00:00 [received]
PHST- 2015/09/28 00:00 [revised]
PHST- 2015/09/29 00:00 [accepted]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
PHST- 2015/10/28 06:00 [entrez]
AID - bjophthalmol-2015-307068 [pii]
AID - 10.1136/bjophthalmol-2015-307068 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2016 Jul;100(7):897-901. doi: 10.1136/bjophthalmol-2015-307068. 
      Epub 2015 Oct 26.