PMID- 26504526
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151027
LR  - 20220330
IS  - 2052-4897 (Print)
IS  - 2052-4897 (Electronic)
IS  - 2052-4897 (Linking)
VI  - 3
IP  - 1
DP  - 2015
TI  - Predictors of the antibody response to influenza vaccination in older adults with 
      type 2 diabetes.
PG  - e000140
LID - 10.1136/bmjdrc-2015-000140 [doi]
LID - e000140
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic 
      inflammatory diseases of the elderly. Its development is related to the 
      alteration of the immune system with aging characterized by immunosenescence and 
      inflamm-aging. In turn, T2DM also alters the immune response. As a consequence, 
      older people with T2DM are more susceptible to influenza and to its complications 
      as compared with healthy controls. Vaccination against influenza has shown poor 
      efficacy in the older population and even less efficacy in patients with 
      diabetes. We studied here the antibody response to vaccination in healthy and 
      diabetic elderly participants. RESEARCH DESIGN AND METHODS: In 2 groups of 
      elderly participants (healthy N=119 and T2DM N=102), we measured the 
      immunogenicity of influenza vaccine by hemagglutination inhibition assays. We 
      assessed several blood and functional parameters as potential predictors of the 
      vaccine efficacy. RESULTS: We found no difference between antibody responses in 
      diabetic elderly compared with healthy elderly. Among the biological and 
      functional determinants, the cytomegalovirus (CMV) serostatus played a more 
      prominent role in determining the magnitude of response. We concluded that in 
      addition to age and diabetic status, immunological history such as CMV status 
      should be taken into account. None of the other biological or functional 
      parameters studied could be reliably linked to the vaccine antibody response in 
      older adults who are not frail including those with well-controlled diabetes. 
      CONCLUSIONS: Our data strongly suggest that influenza vaccine should be 
      administered to elderly patients with T2DM; however, the immune determinants of 
      the antibody response to influenza vaccination should be further investigated.
FAU - McElhaney, Janet E
AU  - McElhaney JE
AD  - Advanced Medical Research Institute of Canada , Sudbury, Ontario , Canada.
FAU - Garneau, Hugo
AU  - Garneau H
AD  - Geriatrics Division, Department of Medicine , Research Center on Aging, 
      University of Sherbrooke , Sherbrooke, Quebec , Canada.
FAU - Camous, Xavier
AU  - Camous X
AD  - Singapore Immunology Network (SIgN), Biopolis , Agency for Science Technology and 
      Research (ASTAR) , Singapore.
FAU - Dupuis, Gilles
AU  - Dupuis G
AD  - Geriatrics Division, Department of Medicine , Research Center on Aging, 
      University of Sherbrooke , Sherbrooke, Quebec , Canada.
FAU - Pawelec, Graham
AU  - Pawelec G
AD  - Center for Medical Research, University of Tuebingen , Tuebingen , Germany.
FAU - Baehl, Sarra
AU  - Baehl S
AD  - Geriatrics Division, Department of Medicine , Research Center on Aging, 
      University of Sherbrooke , Sherbrooke, Quebec , Canada.
FAU - Tessier, Daniel
AU  - Tessier D
AD  - Geriatrics Division, Department of Medicine , Research Center on Aging, 
      University of Sherbrooke , Sherbrooke, Quebec , Canada.
FAU - Frost, Eric H
AU  - Frost EH
AD  - Department of Microbiology and Infectious Diseases , University of Sherbrooke , 
      Sherbrooke, Quebec , Canada.
FAU - Frasca, Daniela
AU  - Frasca D
AD  - Department of Microbiology and Immunology , University of Miami Miller School of 
      Medicine , Miami, Florida , USA.
FAU - Larbi, Anis
AU  - Larbi A
AD  - Singapore Immunology Network (SIgN), Biopolis , Agency for Science Technology and 
      Research (ASTAR) , Singapore.
FAU - Fulop, Tamas
AU  - Fulop T
AD  - Geriatrics Division, Department of Medicine , Research Center on Aging, 
      University of Sherbrooke , Sherbrooke, Quebec , Canada.
LA  - eng
GR  - R21 AG042826/AG/NIA NIH HHS/United States
GR  - R21 AI096446/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20151013
PL  - England
TA  - BMJ Open Diabetes Res Care
JT  - BMJ open diabetes research & care
JID - 101641391
PMC - PMC4611872
OTO - NOTNLM
OT  - Aging
OT  - Biomarkers
OT  - Inflammation
OT  - Vaccination
EDAT- 2015/10/28 06:00
MHDA- 2015/10/28 06:01
PMCR- 2015/10/13
CRDT- 2015/10/28 06:00
PHST- 2015/07/24 00:00 [received]
PHST- 2015/09/11 00:00 [revised]
PHST- 2015/09/16 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2015/10/28 06:01 [medline]
PHST- 2015/10/13 00:00 [pmc-release]
AID - bmjdrc-2015-000140 [pii]
AID - 10.1136/bmjdrc-2015-000140 [doi]
PST - epublish
SO  - BMJ Open Diabetes Res Care. 2015 Oct 13;3(1):e000140. doi: 
      10.1136/bmjdrc-2015-000140. eCollection 2015.