PMID- 26504756
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151027
LR  - 20200930
IS  - 2228-5881 (Print)
IS  - 2251-7308 (Electronic)
IS  - 2228-5881 (Linking)
VI  - 5
IP  - 3
DP  - 2015 Sep
TI  - Formation and Characterization of Beclomethasone Dipropionate Nanoparticles Using 
      Rapid Expansion of Supercritical Solution.
PG  - 343-9
LID - 10.15171/apb.2015.048 [doi]
AB  - PURPOSE: Particle size of Beclometasone Dipropionate (BDP) was reduced by the 
      rapid expansion of supercritical solution (RESS) process, using CO2 as 
      supercritical solvent. Also, the effect of RESS parameters such as extraction 
      pressure, pre-expansion temperature, and weight fraction of co-solvent on the 
      size and distribution of BDP particles were investigated. METHODS: The effects of 
      extraction pressure (200-260 bar), pre-expansion temperature (70-110  degrees C) and 
      weight fraction of menthol as a co-solvent on mean particle size (MPS) of BDP 
      were investigated by design of experiment (DOE). Particles were characterized 
      using Scanning Electron Microscopy (SEM) and Dynamic Light Scattering (DLS). 
      RESULTS: The average sizes of precipitated BDP were between 64.1 and 294 nm. 
      Analysis of variance (ANOVA) showed that extraction pressure was the most 
      significant parameter and a higher extraction pressure caused production of 
      smaller particles. Also, it was found that higher temperature and weight fraction 
      of co-solvent increased the MPS. The interaction effects of extraction 
      pressure-pre-expansion temperature and pre-expansion temperature-co-solvent ratio 
      were significant through the analysis of variance. It was observed that the MPS 
      of precipitated particles was mostly influenced by pressure. CONCLUSION: The 
      smallest MPS of BDP obtained from the RESS process was 65 nm that revealed a 
      significant size reduction from its original MPS of 9 mum. Moreover, a slight 
      change was observed for precipitated particles of BDP into spherical form while 
      the original particles were irregular in shape. RESS process showed as a 
      promising method for production of BDP nanoparticles that may results in 
      improvement of drug's physicochemical properties.
FAU - Hosseinpour, Mohsen
AU  - Hosseinpour M
AD  - Pharmaceutical Engineering Laboratory, Multiphase Processes Department, School of 
      Chemical Engineering, University of Tehran, Tehran, Iran.
FAU - Vatanara, Alireza
AU  - Vatanara A
AD  - Aerosol Research Laboratory, Pharmaceutics Department, Faculty of Pharmacy, 
      Tehran University of Medical Science, Tehran, Iran.
FAU - Zarghami, Reza
AU  - Zarghami R
AD  - Pharmaceutical Engineering Laboratory, Multiphase Processes Department, School of 
      Chemical Engineering, University of Tehran, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20150919
PL  - Iran
TA  - Adv Pharm Bull
JT  - Advanced pharmaceutical bulletin
JID - 101578021
PMC - PMC4616900
OTO - NOTNLM
OT  - Beclometasone Dipropionate
OT  - Nanoparticle
OT  - RESS
OT  - Supercritical
EDAT- 2015/10/28 06:00
MHDA- 2015/10/28 06:01
PMCR- 2015/09/01
CRDT- 2015/10/28 06:00
PHST- 2014/10/16 00:00 [received]
PHST- 2014/12/25 00:00 [revised]
PHST- 2015/01/11 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2015/10/28 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 10.15171/apb.2015.048 [doi]
PST - ppublish
SO  - Adv Pharm Bull. 2015 Sep;5(3):343-9. doi: 10.15171/apb.2015.048. Epub 2015 Sep 
      19.