PMID- 26504855
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20181113
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2015
DP  - 2015
TI  - Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity 
      and Their First-Degree Relatives.
PG  - 453046
LID - 10.1155/2015/453046 [doi]
LID - 453046
AB  - We performed a retrospective study of autoimmune conditions (ACs) in 235 
      hemochromatosis probands at diagnosis by analyzing age, sex, ACs, history of 
      first-degree family members with ACs (FH), diabetes, heavy ethanol consumption, 
      elevated serum ALT/AST, nonalcoholic fatty liver disease, viral hepatitis, 
      cirrhosis, iron removed to achieve iron depletion (QFe), and positivity for human 
      leukocyte antigen (HLA) haplotypes A ( *) 01, B ( *) 08; A ( *) 02, B ( *) 44; A ( *) 
      03, B ( *) 07; A ( *) 03, B ( *) 14; and A ( *) 29, B ( *) 44. There were 138 men 
      (58.7%). Median followup was 19.6 y. One or more of 19 ACs were diagnosed in each 
      of 35 probands (14.9%). Prevalences of Hashimoto's thyroiditis, rheumatoid 
      arthritis, and ankylosing spondylitis were 8.1% (95% CI: [5.1, 12.5]), 1.7% [0.6, 
      4.6], and 0.0085 [0.0015, 0.0337], respectively. Eighteen probands (7.7%) had a 
      FH. Eight probands with ACs had 9 family members with ACs. In a logistic 
      regression, ACs were less likely in men (odds ratio (OR) 0.3 [0.1, 0.6]) and more 
      likely in probands with a FH (OR 4.1 [1.4, 11.8]). Overall ACs risk was not 
      significantly associated with QFe or HLA haplotypes. Estimated survival of 
      probands with and without ACs did not differ significantly. We conclude that ACs 
      are common in hemochromatosis probands, especially women and probands with a FH.
FAU - Barton, James C
AU  - Barton JC
AD  - Southern Iron Disorders Center, Birmingham, AL 35209, USA ; Department of 
      Medicine, University of Alabama at Birmingham, Birmingham, AL 35209, USA.
FAU - Barton, J Clayborn
AU  - Barton JC
AD  - Southern Iron Disorders Center, Birmingham, AL 35209, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20151004
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Codon)
RN  - 0 (HFE protein, human)
RN  - 0 (HLA Antigens)
RN  - 0 (Hemochromatosis Protein)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Membrane Proteins)
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution
MH  - Autoimmune Diseases/genetics/immunology
MH  - *Autoimmunity
MH  - Codon
MH  - Comorbidity
MH  - Disease Susceptibility
MH  - *Family
MH  - Female
MH  - Ferritins/blood/metabolism
MH  - HLA Antigens/genetics/immunology
MH  - Hemochromatosis/epidemiology/*genetics/*immunology/metabolism/mortality
MH  - Hemochromatosis Protein
MH  - Histocompatibility Antigens Class I/*genetics
MH  - *Homozygote
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Middle Aged
MH  - *Mutation
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC4609477
EDAT- 2015/10/28 06:00
MHDA- 2016/05/25 06:00
PMCR- 2015/10/04
CRDT- 2015/10/28 06:00
PHST- 2015/06/18 00:00 [received]
PHST- 2015/08/02 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
PHST- 2015/10/04 00:00 [pmc-release]
AID - 10.1155/2015/453046 [doi]
PST - ppublish
SO  - J Immunol Res. 2015;2015:453046. doi: 10.1155/2015/453046. Epub 2015 Oct 4.