PMID- 26505438
OWN - NLM
STAT- MEDLINE
DCOM- 20160916
LR  - 20231213
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Oct 21
TI  - DNA methyltransferase 3B -149C/T polymorphism and the risk of laryngeal squamous 
      cell carcinoma: a case-control study.
PG  - 12866-71
LID - 10.4238/2015.October.21.6 [doi]
AB  - A variety of molecular epidemiological studies have been conducted to examine the 
      association between the DNMT3B -149C/T polymorphism and cancer susceptibility; 
      however, there has been no study investigating the association between the DNMT3B 
      -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma (LSCC) 
      until now. To determine the role of the DNMT3B -149C/T polymorphism in LSCC, we 
      genotyped 113 patients with LSCC and 110 controls from a Chinese population using 
      polymerase chain reaction-restriction fragment length polymorphism analysis. The 
      chi-square test was used to examine differences in the distributions of genotypes 
      studied between patients and controls. The association between the DNMT3B -149C/T 
      polymorphism and the risk of LSCC was estimated using ORs and their 95%CIs. 
      Genotypic frequencies in the patients with LSCC were not similar to those of the 
      controls, with the differences being statistically significant (P = 0.001). When 
      the DNMT3B -149 CC genotype was used as the reference group, the CT genotype was 
      not associated with LSCC risk (adjusted OR, 2.12; 95%CI = 0.89-5.19; P = 0.07), 
      but the TT genotype was associated with significantly increased risk for LSCC 
      (adjusted OR = 3.27; 95%CI = 1.79-10.66; P = 0.009). Under the recessive model of 
      inheritance, the TT genotype was associated with significantly increased risk for 
      LSCC (adjusted OR = 1.98; 95%CI = 1.12-5.95; P = 0.012), compared with other 
      genotypes. These results suggested that the DNMT3B -149C/T polymorphism is 
      associated with a genetic susceptibility for developing LSCC in a Chinese 
      population.
FAU - Zhang, X M
AU  - Zhang XM
AD  - Department of Otorhinolaryngology, Union Hospital, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Li, S
AU  - Li S
AD  - Department of Otorhinolaryngology, the People's Hospital of Shenzhen Nanshan, 
      Shenzhen, China.
FAU - Zhang, Q M
AU  - Zhang QM
AD  - Department of Otorhinolaryngology, the People's Hospital of Shenzhen Nanshan, 
      Shenzhen, China.
LA  - eng
PT  - Journal Article
DEP - 20151021
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
SB  - IM
MH  - Asian People
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Case-Control Studies
MH  - DNA (Cytosine-5-)-Methyltransferases/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Head and Neck Neoplasms/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Restriction Fragment Length/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - DNA Methyltransferase 3B
EDAT- 2015/10/28 06:00
MHDA- 2016/09/17 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/09/17 06:00 [medline]
AID - gmr6012 [pii]
AID - 10.4238/2015.October.21.6 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Oct 21;14(4):12866-71. doi: 10.4238/2015.October.21.6.