PMID- 26505452
OWN - NLM
STAT- MEDLINE
DCOM- 20160916
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Oct 21
TI  - Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial 
      nitric oxide synthase (eNOS) genes contribute to the development of type 2 
      diabetes mellitus in the Chinese Han population.
PG  - 12993-3002
LID - 10.4238/2015.October.21.20 [doi]
AB  - Impaired antioxidant defense increases the oxidative stress and contributes to 
      the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important 
      antioxidant enzymes. This aim of this study was to verify the association of 
      MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of 
      MnSOD and eight tagSNPs of eNOS were detected using TaqMan technology in 1272 
      healthy controls and 1234 T2DM patients. All study participants were unrelated 
      members of the Han ethnic group in China. In this study, the frequency of the 
      rs4880 MnSOD single nucleotide polymorphisms (SNP) genotype differed 
      significantly between T2DM patients and controls [allele: P = 0.03, genotype: P = 
      0.04, odd's ratio (OR) = 1.26; 95% confidence interval (CI) = 1.07-1.49]. The A-T 
      haplotype and G-T haplotype remained significant in T2DM after Bonferroni 
      correction (P = 1.58 x 10(-6) and 8.00 x 10(-4), respectively) with a global 
      p-value of 7.25 x 10(-8). The rs1799983 and rs891512 SNPs of eNOS differed 
      significantly between T2DM patients and controls [rs1799983: corrected allele: P 
      = 2.10 x 10(-3), corrected genotype: P = 6.30 x 10(-3), OR = 1.43 (95%CI = 
      1.18-1.73); rs891512, corrected allele: P = 3.50 x 10(-3), corrected genotype: P 
      = 9.10 x 10(-3), OR = 1.70 (95%CI = 1.26-2.30)]. Following Bonferroni correction, 
      none of the haplotypes of eNOS were significant in T2DM. These results indicate 
      that common variants in MnSOD and eNOS increased the risk of T2DM in the Chinese 
      Han population.
FAU - Li, J Y
AU  - Li JY
AD  - Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory 
      of Traditional Chinese Clinical Medice, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Tao, F
AU  - Tao F
AD  - Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory 
      of Traditional Chinese Clinical Medice, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Wu, X X
AU  - Wu XX
AD  - Shanghai Technical Institute of Electronics & Information, Shanghai, China.
FAU - Tan, Y Z
AU  - Tan YZ
AD  - Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory 
      of Traditional Chinese Clinical Medice, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - He, L
AU  - He L
AD  - Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
FAU - Lu, H
AU  - Lu H
AD  - Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory 
      of Traditional Chinese Clinical Medice, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151021
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - EC 1.14.13.39 (NOS3 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Diabetes Mellitus, Type 2/*enzymology/*genetics/pathology
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide Synthase Type III/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Superoxide Dismutase/*genetics
EDAT- 2015/10/28 06:00
MHDA- 2016/09/17 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/09/17 06:00 [medline]
AID - gmr6644 [pii]
AID - 10.4238/2015.October.21.20 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Oct 21;14(4):12993-3002. doi: 10.4238/2015.October.21.20.