PMID- 26505651
OWN - NLM
STAT- MEDLINE
DCOM- 20160229
LR  - 20151110
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 143
IP  - Pt A
DP  - 2015 Nov
TI  - Self-rated health and chronic conditions are associated with blood concentrations 
      of persistent organic pollutants in the general population of Catalonia, Spain.
PG  - 211-20
LID - S0013-9351(15)30103-1 [pii]
LID - 10.1016/j.envres.2015.10.005 [doi]
AB  - BACKGROUND: Self-rated health (SRH) is a powerful predictor of mortality, 
      morbidity, and need for health services. SRH generally increases with educational 
      level, and decreases with age, number of chronic conditions, and body mass index 
      (BMI). Because human concentrations of most persistent organic pollutants (POPs) 
      also vary by age, education, and BMI, and because of the physiological and 
      clinical effects of POPs, we hypothesized that body concentrations of POPs are 
      inversely associated with SRH. OBJECTIVES: To analyze the relation between serum 
      concentrations of POPs and SRH in the general population of Catalonia, Spain, 
      taking into account sociodemographic factors and BMI, as well as chronic health 
      conditions and mental disorders, measured by the General Health Questionnaire-12 
      (GHQ-12). METHODS: POP serum concentrations were measured by gas chromatography 
      with electron-capture detection in 919 participants of the Catalan Health 
      Interview Survey. RESULTS: Individuals with higher concentrations of POPs had 
      significantly poorer SRH; e.g., the median concentration of HCB in subjects with 
      poor SRH was twice as high as in subjects with excellent SRH (366 ng/g vs. 169 
      ng/g, respectively; p-value<0.001). In crude models and in models adjusted for 
      sex and BMI, the POPs-SRH association was often dose-dependent, and the 
      likelihood of poor or regular SRH was 2 to 4-times higher in subjects with POP 
      concentrations in the top quartile. In models adjusted for age or for chronic 
      conditions virtually all ORs were near unity. No associations were found between 
      POP levels and GHQ-12. CONCLUSIONS: Individuals with higher concentrations of 
      POPs had significantly poorer SRH, an association likely due to age and chronic 
      conditions, but not to sex, education, social class, BMI, or mental disorders.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Gasull, Magda
AU  - Gasull M
AD  - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Spain; School of Medicine, 
      Universitat Autonoma de Barcelona, Spain.
FAU - Pallares, Natalia
AU  - Pallares N
AD  - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Spain; School of Medicine, 
      Universitat Autonoma de Barcelona, Spain.
FAU - Salcedo, Natalia
AU  - Salcedo N
AD  - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain; 
      School of Medicine, Universitat Autonoma de Barcelona, Spain.
FAU - Pumarega, Jose
AU  - Pumarega J
AD  - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Spain.
FAU - Alonso, Jordi
AU  - Alonso J
AD  - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Spain; Universitat Pompeu 
      Fabra, Catalonia, Spain.
FAU - Porta, Miquel
AU  - Porta M
AD  - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Spain; School of Medicine, 
      Universitat Autonoma de Barcelona, Spain. Electronic address: mporta@imim.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151024
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - *Chronic Disease/epidemiology
MH  - *Diagnostic Self Evaluation
MH  - Educational Status
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Male
MH  - *Mental Disorders/epidemiology
MH  - Middle Aged
MH  - Organic Chemicals/*blood
MH  - Socioeconomic Factors
MH  - Spain
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - Chronic disorders
OT  - GHQ
OT  - Human biomonitoring
OT  - Persistent organic pollutants (POPs)
OT  - Self-rated health
EDAT- 2015/10/28 06:00
MHDA- 2016/03/02 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/07/15 00:00 [received]
PHST- 2015/09/09 00:00 [revised]
PHST- 2015/10/05 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - S0013-9351(15)30103-1 [pii]
AID - 10.1016/j.envres.2015.10.005 [doi]
PST - ppublish
SO  - Environ Res. 2015 Nov;143(Pt A):211-20. doi: 10.1016/j.envres.2015.10.005. Epub 
      2015 Oct 24.