PMID- 26505812
OWN - NLM
STAT- MEDLINE
DCOM- 20160921
LR  - 20161126
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 22
IP  - 1
DP  - 2016 Jan
TI  - Inspiratory Muscle Weakness is Associated With Exercise Intolerance in Patients 
      With Heart Failure With Preserved Ejection Fraction: A Preliminary Study.
PG  - 38-47
LID - S1071-9164(15)01157-4 [pii]
LID - 10.1016/j.cardfail.2015.10.010 [doi]
AB  - BACKGROUND: The relationship between inspiratory muscle weakness (IMW) and 
      exercise intolerance in patients with heart failure with preserved ejection 
      fraction (HFpEF) remains unestablished. METHODS AND RESULTS: The present study 
      enrolled 40 patients with HFpEF (EF >/=45%). IMW was defined as maximum inspiratory 
      pressure <70% normal predicted values. The function of the diaphragm was assessed 
      by means of ultrasound measurement of muscle thickening of the diaphragm. IMW was 
      prevalent in 27.5% of patients. Patients with IMW had significantly lower vital 
      capacity relative to normal predicted values (%VC), lower knee extensor muscle 
      strength in relation to body weight (%KEMS), poorer nutritional status as 
      assessed by means of the Geriatric Nutritional Risk Index, and shorter 6-minute 
      walk distance (6MWD) compared with patients without IMW (all P < .05). Impaired 
      diaphragm muscle thickening at end-inspiration (median value < 3.9 mm) was 
      significantly associated with a high prevalence of IMW and reduced 6MWD (all 
      P < .05). Subgroup analysis showed that IMW was accompanied by a further decrease 
      in 6MWD in patients with restrictive pulmonary dysfunction (%VC <80%) or 
      lower-limb muscle weakness (median %KEMS <30%; all P < .05). CONCLUSIONS: IMW is 
      associated with exercise intolerance in patients with HFpEF.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Yamada, Kensaku
AU  - Yamada K
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Kinugasa, Yoshiharu
AU  - Kinugasa Y
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan. Electronic 
      address: ykinugasa-circ@umin.ac.jp.
FAU - Sota, Takeshi
AU  - Sota T
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Miyagi, Mari
AU  - Miyagi M
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Sugihara, Shinobu
AU  - Sugihara S
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Kato, Masahiko
AU  - Kato M
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Yamamoto, Kazuhiro
AU  - Yamamoto K
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151023
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Diaphragm/diagnostic imaging/*physiopathology
MH  - *Exercise Tolerance
MH  - Female
MH  - Heart Failure/complications/*physiopathology
MH  - Humans
MH  - Male
MH  - Muscle Weakness/etiology/*physiopathology
MH  - Nutritional Status
MH  - Respiratory Function Tests
MH  - *Stroke Volume
MH  - Ultrasonography
OTO - NOTNLM
OT  - Exercise intolerance
OT  - diaphragm
OT  - skeletal muscle
EDAT- 2015/10/28 06:00
MHDA- 2016/09/23 06:00
CRDT- 2015/10/28 06:00
PHST- 2014/12/01 00:00 [received]
PHST- 2015/09/25 00:00 [revised]
PHST- 2015/10/06 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - S1071-9164(15)01157-4 [pii]
AID - 10.1016/j.cardfail.2015.10.010 [doi]
PST - ppublish
SO  - J Card Fail. 2016 Jan;22(1):38-47. doi: 10.1016/j.cardfail.2015.10.010. Epub 2015 
      Oct 23.