PMID- 26505835
OWN - NLM
STAT- MEDLINE
DCOM- 20160607
LR  - 20221207
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 87
DP  - 2016 Jan
TI  - Urinary IP-10, MCP-1, NGAL, Cystatin-C, and KIM-1 Levels in Prenatally Diagnosed 
      Unilateral Hydronephrosis: The Search for an Ideal Biomarker.
PG  - 185-92
LID - S0090-4295(15)00878-X [pii]
LID - 10.1016/j.urology.2015.09.007 [doi]
AB  - OBJECTIVE: To investigate the urinary interferon gamma-induced protein 10 
      (IP-10), monocyte chemotactic protein 1 (MCP-1), neutrophil gelatinase-associated 
      lipocalin (NGAL), cystatin-C, and kidney injury molecule-1 (KIM-1) levels in the 
      management of children with prenatally diagnosed unilateral hydronephrosis. 
      MATERIALS AND METHODS: Twenty-seven children with antenatally diagnosed 
      hydronephrosis were enrolled into the study. The controls consisted of 9 healthy 
      children (6 boys, 3 girls; mean age: 41.77 +/- 5.30 months). Thirteen children (9 
      boys, 4 girls; mean age: 48.46 +/- 21.11 months) underwent pyeloplasty on 
      follow-up; the remaining 14 (13 boys, 1 girl; mean age: 36.57 +/- 14.02 months) 
      were followed up after being diagnosed as having nonobstructive dilatation (NOD). 
      The urinary marker levels were measured in the pyeloplasty, the NOD, and the 
      control groups. RESULTS: The preoperative concentrations of IP-10, MCP-1, NGAL, 
      and KIM-1 were significantly higher in the pyeloplasty group than in the control 
      group (P = .024, P = .002, P = .032, P = .001, respectively). The urinary IP-10 
      and MCP-1 levels were also significantly higher in the pyeloplasty group than in 
      the NOD group (P = .038, P = .037, respectively). There was no significant 
      difference between the pyeloplasty group and the NOD group regarding urinary NGAL 
      and KIM-1. In the pyeloplasty group, urinary marker levels except cystatin-C were 
      significantly decreased in the postoperative period. CONCLUSION: A decrease in 
      levels of IP-10, MCP-1, NGAL, and KIM-1 after pyeloplasty may be used as a 
      predictor of surgical outcome. Additionally, IP-10 and MCP-1 were superior to 
      NGAL and KIM-1 in predicting who required surgery.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Karakus, Serkan
AU  - Karakus S
AD  - Department of Urology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Oktar, Tayfun
AU  - Oktar T
AD  - Department of Urology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey. Electronic address: tayfuno@istanbul.edu.tr.
FAU - Kucukgergin, Canan
AU  - Kucukgergin C
AD  - Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Kalelioglu, Ibrahim
AU  - Kalelioglu I
AD  - Division of Perinatology, Department of Obstetrics and Gynecology, Istanbul 
      Faculty of Medicine, Istanbul University, Istanbul, Turkey.
FAU - Seckin, Sule
AU  - Seckin S
AD  - Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Atar, Arda
AU  - Atar A
AD  - Department of Urology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Ander, Haluk
AU  - Ander H
AD  - Department of Urology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Ziylan, Orhan
AU  - Ziylan O
AD  - Department of Urology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20151023
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL10 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Cystatin C)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Acute-Phase Proteins/*urine
MH  - Biomarkers/urine
MH  - Chemokine CCL2/*urine
MH  - Chemokine CXCL10/*urine
MH  - Child, Preschool
MH  - Cystatin C/*urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Hepatitis A Virus Cellular Receptor 1
MH  - Humans
MH  - Hydronephrosis/diagnosis/surgery/*urine
MH  - Infant
MH  - Lipocalin-2
MH  - Lipocalins/*urine
MH  - Male
MH  - Membrane Glycoproteins/*urine
MH  - Prenatal Diagnosis/*methods
MH  - Preoperative Period
MH  - Prospective Studies
MH  - Proto-Oncogene Proteins/*urine
MH  - Receptors, Virus
MH  - Plastic Surgery Procedures
MH  - Urinalysis
MH  - Urologic Surgical Procedures/methods
EDAT- 2015/10/28 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/05/29 00:00 [received]
PHST- 2015/08/26 00:00 [revised]
PHST- 2015/09/05 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - S0090-4295(15)00878-X [pii]
AID - 10.1016/j.urology.2015.09.007 [doi]
PST - ppublish
SO  - Urology. 2016 Jan;87:185-92. doi: 10.1016/j.urology.2015.09.007. Epub 2015 Oct 
      23.