PMID- 26506114
OWN - NLM
STAT- MEDLINE
DCOM- 20160614
LR  - 20181202
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 15
IP  - 2
DP  - 2016 Feb
TI  - Dividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis 
      with polyangitis.
PG  - 139-45
LID - S1568-9972(15)00218-9 [pii]
LID - 10.1016/j.autrev.2015.10.006 [doi]
AB  - Eosinophilic granulomatosis with polyangitis (EGPA) is a rare small- and 
      medium-sized vessel vasculitis belonging to the group of anti-neutrophil 
      cytoplasm antibody (ANCA)-associated vasculitides (AAV). It is commonly divided 
      into two phenotypes depending on the presence of ANCAs targeting myeloperoxidase 
      (MPO). MPO-ANCAs are present in 31% to 38% of patients and are associated with a 
      vasculitis phenotype of the disease, whereas patients without MPO-ANCA are at 
      risk of cardiac involvement. Despite significant advances in understanding the 
      overall pathogenesis of the disease, the explanation for this dichotomy is still 
      unclear. In this review, we synthesize our knowledge of the pathogenesis of EGPA 
      and attempt to i) distinguish EGPA from other diseases including other AAVs, 
      asthma, allergy and hypereosinophilic-associated conditions and ii) speculate 
      about the preponderant mechanisms, which could explain the two disease 
      phenotypes.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Chaigne, Benjamin
AU  - Chaigne B
AD  - INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France; Universite Paris 
      Descartes, Faculte de Medecine, Pole de Medecine Interne, Centre de reference 
      pour les vascularites necrosantes et la sclerodermie systemique, hopital Cochin, 
      Assistance Publique-Hopitaux de Paris, Paris, France.
FAU - Terrier, Benjamin
AU  - Terrier B
AD  - INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France; Universite Paris 
      Descartes, Faculte de Medecine, Pole de Medecine Interne, Centre de reference 
      pour les vascularites necrosantes et la sclerodermie systemique, hopital Cochin, 
      Assistance Publique-Hopitaux de Paris, Paris, France.
FAU - Thieblemont, Nathalie
AU  - Thieblemont N
AD  - INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
FAU - Witko-Sarsat, Veronique
AU  - Witko-Sarsat V
AD  - INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
FAU - Mouthon, Luc
AU  - Mouthon L
AD  - INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France; Universite Paris 
      Descartes, Faculte de Medecine, Pole de Medecine Interne, Centre de reference 
      pour les vascularites necrosantes et la sclerodermie systemique, hopital Cochin, 
      Assistance Publique-Hopitaux de Paris, Paris, France. Electronic address: 
      luc.mouthon@cch.aphp.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151023
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Animals
MH  - Antibodies, Antineutrophil Cytoplasmic/immunology
MH  - Asthma/complications
MH  - B-Lymphocytes/immunology
MH  - Eosinophils/*immunology
MH  - Granulomatosis with Polyangiitis/complications/*immunology
MH  - Humans
MH  - Peroxidase/immunology
OTO - NOTNLM
OT  - ANCA-MPO
OT  - Eosinophilia
OT  - Eosinophilic granulomatosis with polyangitis
OT  - Th2 response
OT  - Vasculitis
EDAT- 2015/10/28 06:00
MHDA- 2016/06/15 06:00
CRDT- 2015/10/28 06:00
PHST- 2015/10/02 00:00 [received]
PHST- 2015/10/15 00:00 [accepted]
PHST- 2015/10/28 06:00 [entrez]
PHST- 2015/10/28 06:00 [pubmed]
PHST- 2016/06/15 06:00 [medline]
AID - S1568-9972(15)00218-9 [pii]
AID - 10.1016/j.autrev.2015.10.006 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2016 Feb;15(2):139-45. doi: 10.1016/j.autrev.2015.10.006. Epub 
      2015 Oct 23.