PMID- 26507122
OWN - NLM
STAT- MEDLINE
DCOM- 20160623
LR  - 20181202
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 183
IP  - 3
DP  - 2016 Mar
TI  - Human umbilical cord derived mesenchymal stem cells promote interleukin-17 
      production from human peripheral blood mononuclear cells of healthy donors and 
      systemic lupus erythematosus patients.
PG  - 389-96
LID - 10.1111/cei.12737 [doi]
AB  - Inflammation instigated by interleukin (IL)-17-producing cells is central to the 
      development and pathogenesis of several human autoimmune diseases and animal 
      models of autoimmunity. The expansion of IL-17-producing cells from healthy 
      donors is reportedly promoted by mesenchymal stem cells derived from fetal bone 
      marrow. In the present study, human umbilical cord-derived mesenchymal stem cells 
      (hUC-MSCs) were examined for their effects on lymphocytes from healthy donors and 
      from patients with systemic lupus erythematosus (SLE). Significantly higher 
      levels of IL-17 were produced when CD4(+) T cells from healthy donors were 
      co-cultured with hUC-MSCs than those that were cultured alone. Blocking 
      experiments identified that this effect might be mediated partially through 
      prostaglandin E2 (PGE2 ) and IL-1beta, without IL-23 involvement. We then 
      co-cultured hUC-MSCs with human CD4(+) T cells from systemic lupus erythematosus 
      patients. Ex-vivo inductions of IL-17 by hUC-MSCs in stimulated lymphocytes were 
      significantly higher in SLE patients than in healthy donors. This effect was not 
      observed for IL-23. Taken together, our results represent that hUC-MSCs can 
      promote the IL-17 production from CD4(+) T cells in both healthy donor and SLE 
      patients. PGE2 and IL-1beta might also be partially involved in the promotive effect 
      of hUC-MSCs.
CI  - (c) 2015 British Society for Immunology.
FAU - Ren, S
AU  - Ren S
AD  - Department of Hematology, National Center for Clinical Laboratories and Beijing 
      Hospital, Beijing, China.
FAU - Hu, J
AU  - Hu J
AD  - Department of Hematology, National Center for Clinical Laboratories and Beijing 
      Hospital, Beijing, China.
FAU - Chen, Y
AU  - Chen Y
AD  - Department of Hepatobiliary Surgery, General Hospital of Beijing Military Area 
      Command, Beijing, China.
FAU - Yuan, T
AU  - Yuan T
AD  - Department of Hematology, National Center for Clinical Laboratories and Beijing 
      Hospital, Beijing, China.
FAU - Hu, H
AU  - Hu H
AD  - Department of Hematology, National Center for Clinical Laboratories and Beijing 
      Hospital, Beijing, China.
FAU - Li, S
AU  - Li S
AD  - Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline 
      of Pediatrics, Ministry of Education, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Hematology Oncology Center, Beijing Children's 
      Hospital, Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151216
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (IL17A protein, human)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-23)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cell Proliferation
MH  - Coculture Techniques
MH  - Dinoprostone/metabolism
MH  - Healthy Volunteers
MH  - Humans
MH  - Interleukin-17/*biosynthesis
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-23/blood
MH  - Leukocytes, Mononuclear/*immunology
MH  - Lupus Erythematosus, Systemic/*immunology
MH  - Mesenchymal Stem Cells/*immunology
MH  - Umbilical Cord/*cytology
PMC - PMC4750599
OTO - NOTNLM
OT  - IL-17
OT  - SLE
OT  - hUC-MSCs
OT  - prostaglandin E2
EDAT- 2015/10/29 06:00
MHDA- 2016/06/24 06:00
PMCR- 2017/03/01
CRDT- 2015/10/29 06:00
PHST- 2015/10/22 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2015/10/29 06:00 [entrez]
PHST- 2015/10/29 06:00 [pubmed]
PHST- 2016/06/24 06:00 [medline]
AID - CEI12737 [pii]
AID - 10.1111/cei.12737 [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2016 Mar;183(3):389-96. doi: 10.1111/cei.12737. Epub 2015 Dec 
      16.