PMID- 26507541
OWN - NLM
STAT- MEDLINE
DCOM- 20161020
LR  - 20161230
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 27
DP  - 2016 Jan
TI  - Macronutrient composition determines accumulation of persistent organic 
      pollutants from dietary exposure in adipose tissue of mice.
PG  - 307-16
LID - S0955-2863(15)00255-7 [pii]
LID - 10.1016/j.jnutbio.2015.09.019 [doi]
AB  - Accumulation of persistent organic pollutants (POPs) has been linked to adipose 
      tissue expansion. As different nutrients modulate adipose tissue development, we 
      investigated the influence of dietary composition on POP accumulation, obesity 
      development and related disorders. Lifespan was determined in mice fed 
      fish-oil-based high fat diets during a long-term feeding trial and accumulation 
      of POPs was measured after 3, 6 and 18months of feeding. Further, we performed 
      dose-response experiments using four abundant POPs found in marine sources, 
      PCB-153, PCB-138, PCB-118 and pp'-DDE as single congeners or as mixtures in 
      combination with different diets: one low fat diet and two high fat diets with 
      different protein:sucrose ratios. We measured accumulation of POPs in adipose 
      tissue and liver and determined obesity development, glucose tolerance, insulin 
      sensitivity and hepatic expression of genes involved in metabolism of 
      xenobiotics. Compared with mice fed diets with a low protein:sucrose ratio, mice 
      fed diets with a high protein:sucrose ratio had significantly lower total burden 
      of POPs in adipose tissue, were protected from obesity development and exhibited 
      enhanced hepatic expression of genes involved in metabolism and elimination of 
      xenobiotics. Exposure to POPs, either as single compounds or mixtures, had no 
      effect on obesity development, glucose tolerance or insulin sensitivity. In 
      conclusion, this study demonstrates that the dietary composition of 
      macronutrients profoundly modulates POP accumulation in adipose tissues adding an 
      additional parameter to be included in future studies. Our results indicate that 
      alterations in macronutrient composition might be an additional route for 
      reducing total body burden of POPs.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Myrmel, Lene Secher
AU  - Myrmel LS
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark; National Institute of 
      Nutrition and Seafood Research, 5817 Bergen, Norway.
FAU - Fjaere, Even
AU  - Fjaere E
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark; National Institute of 
      Nutrition and Seafood Research, 5817 Bergen, Norway.
FAU - Midtbo, Lisa Kolden
AU  - Midtbo LK
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark; National Institute of 
      Nutrition and Seafood Research, 5817 Bergen, Norway.
FAU - Bernhard, Annette
AU  - Bernhard A
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark; National Institute of 
      Nutrition and Seafood Research, 5817 Bergen, Norway.
FAU - Petersen, Rasmus Koefoed
AU  - Petersen RK
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark.
FAU - Sonne, Si Brask
AU  - Sonne SB
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark.
FAU - Mortensen, Alicja
AU  - Mortensen A
AD  - Division of Risk Assessment and Nutrition, National Food Institute, Technical 
      University of Denmark, 2800 Copenhagen, Denmark.
FAU - Hao, Qin
AU  - Hao Q
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark.
FAU - Brattelid, Trond
AU  - Brattelid T
AD  - National Institute of Nutrition and Seafood Research, 5817 Bergen, Norway.
FAU - Liaset, Bjorn
AU  - Liaset B
AD  - National Institute of Nutrition and Seafood Research, 5817 Bergen, Norway.
FAU - Kristiansen, Karsten
AU  - Kristiansen K
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address: 
      kk@bio.ku.dk.
FAU - Madsen, Lise
AU  - Madsen L
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, 2100 Copenhagen, Denmark; National Institute of 
      Nutrition and Seafood Research, 5817 Bergen, Norway. Electronic address: 
      lise.madsen@nifes.no.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151021
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - *Diet
MH  - Environmental Pollutants/*pharmacokinetics
MH  - Female
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Organic Chemicals/*pharmacokinetics
OTO - NOTNLM
OT  - Glucose tolerance
OT  - Insulin sensitivity
OT  - Macronutrients
OT  - Obesity
OT  - Persistent organic pollutants
EDAT- 2015/10/29 06:00
MHDA- 2016/10/21 06:00
CRDT- 2015/10/29 06:00
PHST- 2015/05/18 00:00 [received]
PHST- 2015/09/08 00:00 [revised]
PHST- 2015/09/22 00:00 [accepted]
PHST- 2015/10/29 06:00 [entrez]
PHST- 2015/10/29 06:00 [pubmed]
PHST- 2016/10/21 06:00 [medline]
AID - S0955-2863(15)00255-7 [pii]
AID - 10.1016/j.jnutbio.2015.09.019 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2016 Jan;27:307-16. doi: 10.1016/j.jnutbio.2015.09.019. Epub 2015 
      Oct 21.