PMID- 26508964
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151028
LR  - 20200930
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 12
IP  - 4
DP  - 2015 Oct
TI  - A Longitudinal Study of BDNF Promoter Methylation and Depression in Breast 
      Cancer.
PG  - 523-31
LID - 10.4306/pi.2015.12.4.523 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is investigated in depression 
      related to medical disorders and its secretion is influenced by epigenetic 
      factors. We investigated the association between BDNF promoter methylation and 
      depression following mastectomy for breast cancer. METHODS: In total, 309 
      patients with breast cancer were evaluated 1 week after mastectomy, and 244 (79%) 
      were followed up 1 year later. Depression was diagnosed (major or minor 
      depressive disorder) according to DSM-IV criteria and depression severity was 
      estimated by Montgomery-Asberg Depression Rating Scale (MADRS). We assessed BDNF 
      promoter methylation using leukocyte DNA. The effects of BDNF methylation on 
      depression diagnosis and severity were investigated using multivariate logistic 
      and linear regression models, respectively. The two-way interaction between BDNF 
      methylation and the val66met polymorphism on depression was also evaluated using 
      multivariate logistic regression models. RESULTS: Higher BDNF methylation was 
      independently associated with depression diagnosis and with more severe symptoms 
      at both 1 week and 1 year after mastectomy. No significant methylation-genotype 
      interactions were found. CONCLUSION: A role for BDNF in depression related to 
      breast cancer was supported. Indeed, the association between depression and BDNF 
      methylation may be useful for identifying patients who are at high risk for 
      depression and for suggesting directions for promising drug research.
FAU - Kang, Hee-Ju
AU  - Kang HJ
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Seon-Young
AU  - Kim SY
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Sung-Wan
AU  - Kim SW
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Shin, Il-Seon
AU  - Shin IS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Hye-Ran
AU  - Kim HR
AD  - Brain Korea 21 Project, Center for Biomedical Human Resources, Chonnam National 
      University Medical School, Gwangju, Republic of Korea.
FAU - Park, Min-Ho
AU  - Park MH
AD  - Breast and Endocrine Tumor Clinic, Chonnam National University Hwasun Hospital, 
      Hwasun, Republic of Korea.
FAU - Shin, Myung-Geun
AU  - Shin MG
AD  - Department of Laboratory Medicine, Chonnam National University Medical School, 
      Gwangju, Republic of Korea.
FAU - Yoon, Jung-Han
AU  - Yoon JH
AD  - Breast and Endocrine Tumor Clinic, Chonnam National University Hwasun Hospital, 
      Hwasun, Republic of Korea.
FAU - Yoon, Jin-Sang
AU  - Yoon JS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20150930
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC4620310
OTO - NOTNLM
OT  - BDNF
OT  - Breast cancer
OT  - DNA methylation
OT  - Depression
OT  - Epigenetics
EDAT- 2015/10/29 06:00
MHDA- 2015/10/29 06:01
PMCR- 2015/10/01
CRDT- 2015/10/29 06:00
PHST- 2014/11/11 00:00 [received]
PHST- 2014/12/02 00:00 [revised]
PHST- 2014/11/02 00:00 [accepted]
PHST- 2015/10/29 06:00 [entrez]
PHST- 2015/10/29 06:00 [pubmed]
PHST- 2015/10/29 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 10.4306/pi.2015.12.4.523 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2015 Oct;12(4):523-31. doi: 10.4306/pi.2015.12.4.523. Epub 
      2015 Sep 30.