PMID- 26510938
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20211203
IS  - 1573-6601 (Electronic)
IS  - 0047-2891 (Linking)
VI  - 45
IP  - 3
DP  - 2016 Mar
TI  - The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing 
      Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model.
PG  - 471-83
LID - 10.1007/s10964-015-0378-x [doi]
AB  - Although depressive symptoms are common during adolescence, little research has 
      examined gene-environment interaction on youth depression. This study chose the 
      brain-derived neurotrophic factor (BDNF) gene, tested the interaction between a 
      functional polymorphism resulting amino acid substitution of valine (Val) to 
      methionine (Met) in the proBDNF protein at codon 66 (Val66Met), and maternal 
      parenting on youth depressive symptoms in a sample of 780 community adolescents 
      of Chinese Han ethnicity (aged 11-17, M = 13.6, 51.3 % females). Participants 
      reported their depressive symptoms and perceived maternal parenting. Results 
      indicated the BDNF Val66Met polymorphism significantly moderated the influence of 
      maternal warmth-reasoning, but not harshness-hostility, on youth depressive 
      symptoms. Confirmatory model evaluation indicated that the interaction effect 
      involving warmth-reasoning conformed to the differential-susceptibility rather 
      than diathesis-stress model of person-X-environment interaction. Thus, Val 
      carriers experienced less depressive symptoms than Met homozygotes when mothering 
      was more positive but more symptoms when mothering was less positive. The 
      findings provided evidence in support of the differential susceptibility 
      hypothesis of youth depressive symptoms and shed light on the importance of 
      examining the gene-environment interaction from a developmental perspective.
FAU - Zhang, Leilei
AU  - Zhang L
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
FAU - Li, Zhi
AU  - Li Z
AD  - Department of Human Ecology, University of California, Davis, CA, USA.
FAU - Chen, Jie
AU  - Chen J
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China. 
      chenjie@psych.ac.cn.
FAU - Li, Xinying
AU  - Li X
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
FAU - Zhang, Jianxin
AU  - Zhang J
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
FAU - Belsky, Jay
AU  - Belsky J
AD  - Department of Human Ecology, University of California, Davis, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Twin Study
DEP - 20151028
PL  - United States
TA  - J Youth Adolesc
JT  - Journal of youth and adolescence
JID - 0333507
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - China
MH  - Depression/*genetics/psychology
MH  - Ethnicity
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Mother-Child Relations/*psychology
MH  - Mothers
MH  - *Parenting
MH  - *Polymorphism, Genetic
OTO - NOTNLM
OT  - Adolescent depressive symptoms
OT  - BDNF Val66Met polymorphism
OT  - Differential susceptibility
OT  - Gene-environment interaction
OT  - Maternal parenting
EDAT- 2015/10/30 06:00
MHDA- 2016/11/01 06:00
CRDT- 2015/10/30 06:00
PHST- 2015/07/21 00:00 [received]
PHST- 2015/10/22 00:00 [accepted]
PHST- 2015/10/30 06:00 [entrez]
PHST- 2015/10/30 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - 10.1007/s10964-015-0378-x [pii]
AID - 10.1007/s10964-015-0378-x [doi]
PST - ppublish
SO  - J Youth Adolesc. 2016 Mar;45(3):471-83. doi: 10.1007/s10964-015-0378-x. Epub 2015 
      Oct 28.