PMID- 26512023
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20191114
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 65
IP  - 3
DP  - 2016 Mar
TI  - n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the 
      Hypothalamus.
PG  - 673-86
LID - 10.2337/db15-0008 [doi]
AB  - Apoptosis of hypothalamic neurons is believed to play an important role in the 
      development and perpetuation of obesity. Similar to the hippocampus, the 
      hypothalamus presents constitutive and stimulated neurogenesis, suggesting that 
      obesity-associated hypothalamic dysfunction can be repaired. Here, we explored 
      the hypothesis that n-3 polyunsaturated fatty acids (PUFAs) induce hypothalamic 
      neurogenesis. Both in the diet and injected directly into the hypothalamus, PUFAs 
      were capable of increasing hypothalamic neurogenesis to levels similar or 
      superior to the effect of brain-derived neurotrophic factor (BDNF). Most of the 
      neurogenic activity induced by PUFAs resulted in increased numbers of 
      proopiomelanocortin but not NPY neurons and was accompanied by increased 
      expression of BDNF and G-protein-coupled receptor 40 (GPR40). The inhibition of 
      GPR40 was capable of reducing the neurogenic effect of a PUFA, while the 
      inhibition of BDNF resulted in the reduction of global hypothalamic cell. Thus, 
      PUFAs emerge as a potential dietary approach to correct obesity-associated 
      hypothalamic neuronal loss.
CI  - (c) 2016 by the American Diabetes Association. Readers may use this article as long 
      as the work is properly cited, the use is educational and not for profit, and the 
      work is not altered.
FAU - Nascimento, Lucas F R
AU  - Nascimento LF
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
FAU - Souza, Gabriela F P
AU  - Souza GF
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
FAU - Morari, Joseane
AU  - Morari J
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
FAU - Barbosa, Guilherme O
AU  - Barbosa GO
AD  - Department of Cell Biology, University of Campinas, Campinas, Brazil.
FAU - Solon, Carina
AU  - Solon C
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
FAU - Moura, Rodrigo F
AU  - Moura RF
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
FAU - Victorio, Sheila C
AU  - Victorio SC
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
FAU - Ignacio-Souza, Leticia M
AU  - Ignacio-Souza LM
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
FAU - Razolli, Daniela S
AU  - Razolli DS
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
FAU - Carvalho, Hernandes F
AU  - Carvalho HF
AD  - Department of Cell Biology, University of Campinas, Campinas, Brazil.
FAU - Velloso, Licio A
AU  - Velloso LA
AD  - Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil 
      lavelloso.unicamp@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151028
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Ffar1 protein, mouse)
RN  - 0 (Neuropeptide Y)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
SB  - IM
CIN - Diabetes. 2016 Mar;65(3):551-3. PMID: 26908906
MH  - Animals
MH  - Blood Glucose/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/drug effects/genetics/metabolism
MH  - Fatty Acids, Omega-3/*pharmacology
MH  - Glucose Tolerance Test
MH  - Hypothalamus/cytology/*drug effects/metabolism
MH  - Mice
MH  - Neurogenesis/*drug effects
MH  - Neurons/*drug effects/metabolism
MH  - Neuropeptide Y
MH  - Pro-Opiomelanocortin/metabolism
MH  - RNA, Messenger/*drug effects/metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, G-Protein-Coupled/drug effects/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2015/10/30 06:00
MHDA- 2016/07/07 06:00
CRDT- 2015/10/30 06:00
PHST- 2015/06/05 00:00 [received]
PHST- 2015/10/17 00:00 [accepted]
PHST- 2015/10/30 06:00 [entrez]
PHST- 2015/10/30 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
AID - db15-0008 [pii]
AID - 10.2337/db15-0008 [doi]
PST - ppublish
SO  - Diabetes. 2016 Mar;65(3):673-86. doi: 10.2337/db15-0008. Epub 2015 Oct 28.