PMID- 26512599
OWN - NLM
STAT- MEDLINE
DCOM- 20160208
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 43
DP  - 2015 Oct
TI  - Characterization of Benign Myocarditis Using Quantitative Delayed-Enhancement 
      Imaging Based on Molli T1 Mapping.
PG  - e1868
LID - 10.1097/MD.0000000000001868 [doi]
LID - e1868
AB  - Delayed contrast enhancement after injection of a gadolinium-chelate (Gd-chelate) 
      is a reference imaging method to detect myocardial tissue changes. Its 
      localization within the thickness of the myocardial wall allows differentiating 
      various pathological processes such as myocardial infarction (MI), inflammatory 
      myocarditis, and cardiomyopathies. The aim of the study was first to characterize 
      benign myocarditis using quantitative delayed-enhancement imaging and then to 
      investigate whether the measure of the extracellular volume fraction (ECV) can be 
      used to discriminate between MI and myocarditis.In 6 patients with acute benign 
      myocarditis (32.2 +/- 13.8 year-old, subepicardial late gadolinium enhancement 
      [LGE]) and 18 patients with MI (52.3 +/- 10.9 year-old, subendocardial/transmural 
      LGE), myocardial T1 was determined using the Modified Look-Locker Imaging (MOLLI) 
      sequence at 3 Tesla before and after Gd-chelate injection. T1 values were 
      compared in LGE and normal regions of the myocardium. The myocardial T1 values 
      were normalized to the T1 of blood, and the ECV was calculated from T1 values of 
      myocardium and blood pre- and post-Gd injection.In both myocarditis and MI, the 
      T1 was lower in LGE regions than in normal regions of the left ventricle. T1 of 
      LGE areas was significantly higher in myocarditis than in MI (446.8 +/- 45.8 vs 
      360.5 +/- 66.9 ms, P = 0.003) and ECV was lower in myocarditis than in MI 
      (34.5 +/- 3.3 vs 53.8 +/- 13.0 %, P = 0.004).Both inflammatory process and chronic 
      fibrosis induce LGE (subepicardial in myocarditis and subendocardial in MI). The 
      present study demonstrates that the determination of T1 and ECV is able to 
      differentiate the 2 histological patterns.Further investigation will indicate 
      whether the severity of ECV changes might help refine the predictive risk of LGE 
      in myocarditis.
FAU - Toussaint, Marcel
AU  - Toussaint M
AD  - From the Hopital Pitie-Salpetriere, Institut de Myologie and CEA, NMR Laboratory, 
      Paris (MT, RJG, NA, BM, PGC); Hopital Sud-Francilien, Corbeil-Essonnes (MT); 
      MIRCen, I2BM, CEA, Paris, France (NA, BM, PGC); CHWAPI, Tournai, Belgium (RJG); 
      Siemens Healthcare, Saint-Denis, France (AV); and Siemens AG Healthcare Sector, 
      Erlangen, Germany (AG).
FAU - Gilles, Raymond J
AU  - Gilles RJ
FAU - Azzabou, Noura
AU  - Azzabou N
FAU - Marty, Benjamin
AU  - Marty B
FAU - Vignaud, Alexandre
AU  - Vignaud A
FAU - Greiser, Andreas
AU  - Greiser A
FAU - Carlier, Pierre G
AU  - Carlier PG
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Cardiac Imaging Techniques
MH  - Extracellular Fluid
MH  - Female
MH  - Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis
MH  - Myocarditis/*pathology
MH  - Myocardium/*pathology
MH  - Young Adult
PMC - PMC4985413
COIS- The authors have no conflicts of interest to declare.
EDAT- 2015/10/30 06:00
MHDA- 2016/02/09 06:00
PMCR- 2015/10/30
CRDT- 2015/10/30 06:00
PHST- 2015/10/30 06:00 [entrez]
PHST- 2015/10/30 06:00 [pubmed]
PHST- 2016/02/09 06:00 [medline]
PHST- 2015/10/30 00:00 [pmc-release]
AID - 00005792-201510270-00054 [pii]
AID - 10.1097/MD.0000000000001868 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Oct;94(43):e1868. doi: 10.1097/MD.0000000000001868.