PMID- 26513200
OWN - NLM
STAT- MEDLINE
DCOM- 20171011
LR  - 20181113
IS  - 2164-554X (Electronic)
IS  - 2164-5515 (Print)
IS  - 2164-5515 (Linking)
VI  - 12
IP  - 3
DP  - 2016 Mar 3
TI  - Dendritic cell targeted vaccines: Recent progresses and challenges.
PG  - 612-22
LID - 10.1080/21645515.2015.1105415 [doi]
AB  - Dendritic cells (DCs) are known to be a set of morphology, structure and function 
      of heterogeneous professional antigen presenting cells (APCs), as well as the 
      strongest functional antigen presenting cells, which can absorb, process and 
      present antigens. As the key regulators of innate and adaptive immune responses, 
      DCs are at the center of the immune system and capable of interacting with both B 
      cells and T cells, thereby manipulating the humoral and cellular immune 
      responses. DCs provide an essential link between the innate and adaptive 
      immunity, and the strong immune activation function of DCs and their properties 
      of natural adjuvants, make them a valuable target for antigen delivery. Targeting 
      antigens to DC-specific endocytic receptors in combination with the relevant 
      antibodies or ligands along with immunostimulatory adjuvants has been recently 
      recognized as a promising strategy for designing an effective vaccine that 
      elicits a strong and durable T cell response against intracellular pathogens and 
      cancer. This opinion article provides a brief summary of the rationales, 
      superiorities and challenges of existing DC-targeting approaches.
FAU - Chen, Pengfei
AU  - Chen P
AD  - a State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and 
      Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry 
      of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of 
      Agricultural Sciences , Lanzhou , China.
FAU - Liu, Xinsheng
AU  - Liu X
AD  - a State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and 
      Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry 
      of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of 
      Agricultural Sciences , Lanzhou , China.
FAU - Sun, Yuefeng
AU  - Sun Y
AD  - a State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and 
      Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry 
      of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of 
      Agricultural Sciences , Lanzhou , China.
FAU - Zhou, Peng
AU  - Zhou P
AD  - a State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and 
      Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry 
      of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of 
      Agricultural Sciences , Lanzhou , China.
FAU - Wang, Yonglu
AU  - Wang Y
AD  - a State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and 
      Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry 
      of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of 
      Agricultural Sciences , Lanzhou , China.
FAU - Zhang, Yongguang
AU  - Zhang Y
AD  - a State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and 
      Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry 
      of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of 
      Agricultural Sciences , Lanzhou , China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Vaccin Immunother
JT  - Human vaccines & immunotherapeutics
JID - 101572652
RN  - 0 (Vaccines)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - *Antigen Presentation
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Innate
MH  - T-Lymphocytes/immunology
MH  - Vaccines/*administration & dosage
PMC - PMC4964742
OTO - NOTNLM
OT  - Dendritic cells
OT  - cellular immunity
OT  - humoral immunity
OT  - target
OT  - vaccine
EDAT- 2015/10/30 06:00
MHDA- 2017/10/12 06:00
PMCR- 2016/10/29
CRDT- 2015/10/30 06:00
PHST- 2015/10/30 06:00 [entrez]
PHST- 2015/10/30 06:00 [pubmed]
PHST- 2017/10/12 06:00 [medline]
PHST- 2016/10/29 00:00 [pmc-release]
AID - 1105415 [pii]
AID - 10.1080/21645515.2015.1105415 [doi]
PST - ppublish
SO  - Hum Vaccin Immunother. 2016 Mar 3;12(3):612-22. doi: 
      10.1080/21645515.2015.1105415.