PMID- 26513380
OWN - NLM
STAT- MEDLINE
DCOM- 20170601
LR  - 20171116
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 29
IP  - 18
DP  - 2016 Sep
TI  - The association of HLA-G and immune markers in recurrent miscarriages.
PG  - 3056-60
LID - 10.3109/14767058.2015.1114085 [doi]
AB  - OBJECTIVE: To determine role of human leukocyte antigen (HLA)-G, CD8, CD16, CD56, 
      interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha for recurrent miscarriages 
      in feto-maternal interface. METHOD: Chorion and decidua samples were obtained 
      from 11 women with unwanted pregnancies (healthy pregnancy, HP) and 10 women with 
      missed abortion diagnosis after at least two pregnancy losses (recurrent 
      miscarriage, RM). In addition, endometrial tissues were obtained from 10 
      non-pregnant women (NonP). The expressions of markers were evaluated using the 
      Western blot analysis. The values obtained between different groups were 
      compared. RESULTS: The highest protein expression of CD56 was found in the HP 
      compared to NonP and RM. Meanwhile, the lowest protein expression of CD16 was 
      observed in the NonP compared to HP and RM. The HLA-G expression exhibited the 
      highest level in HP; however, there was no statistically significant difference 
      between groups. CD8 and IFNgamma expressions were lowest in the NonP group; however, 
      TNF-alpha was highest in the RM group. CONCLUSIONS: The CD56 expression of uterine NK 
      cells may be an indicator of a HP. However, not statistically significant, the 
      increased expression of CD16, CD8, and also significantly increased expression of 
      TNF may be associated with the predominant cytotoxic activity in the maternal 
      immune system in patients with RM. Although there was no change in the expression 
      of HLA-G, this finding may mean that the maternal immune system is unresponsive 
      to HLA-G-mediated immunosuppressive signals originating from the fetus in these 
      cases.
FAU - Eskicioglu, Fatma
AU  - Eskicioglu F
AD  - a Department of Obstetrics and Gynecology , School of Medicine, Celal Bayar 
      University , Manisa , Turkey .
FAU - Ozdemir, Alper Tunga
AU  - Ozdemir AT
AD  - b Department of Stem Cell , Institute of Health Sciences, Ege University , Izmir 
      , Turkey .
FAU - Ozdemir, Rabia Bilge
AU  - Ozdemir RB
AD  - c Department of Immunology and Allergy , School of Medicine, Celal Bayar 
      University , Manisa , Turkey .
FAU - Turan, Guluzar Arzu
AU  - Turan GA
AD  - d Department of Obstetrics and Gynecology , School of Medicine, Sifa University , 
      Izmir , Turkey , and.
FAU - Akan, Zafer
AU  - Akan Z
AD  - e Department of Biophysics , School of Medicine, Celal Bayar University , Manisa 
      , Turkey.
FAU - Hasdemir, Solmaz Pinar
AU  - Hasdemir SP
AD  - a Department of Obstetrics and Gynecology , School of Medicine, Celal Bayar 
      University , Manisa , Turkey .
LA  - eng
PT  - Journal Article
DEP - 20151130
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Biomarkers)
RN  - 0 (CD56 Antigen)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Abortion, Habitual/*metabolism
MH  - Adult
MH  - Biomarkers/analysis
MH  - Blotting, Western
MH  - CD56 Antigen/*analysis
MH  - Decidua
MH  - Female
MH  - HLA-G Antigens/*analysis
MH  - Humans
MH  - Interferon-gamma/*analysis
MH  - Killer Cells, Natural/*chemistry
MH  - Pregnancy
MH  - Prospective Studies
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - Young Adult
OTO - NOTNLM
OT  - CD8-Positive T-Lymphocytes
OT  - HLA-G
OT  - natural killer cells
OT  - recurrent miscarriages
EDAT- 2015/10/30 06:00
MHDA- 2017/06/02 06:00
CRDT- 2015/10/30 06:00
PHST- 2015/10/30 06:00 [entrez]
PHST- 2015/10/30 06:00 [pubmed]
PHST- 2017/06/02 06:00 [medline]
AID - 10.3109/14767058.2015.1114085 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2016 Sep;29(18):3056-60. doi: 
      10.3109/14767058.2015.1114085. Epub 2015 Nov 30.