PMID- 26513999
OWN - NLM
STAT- MEDLINE
DCOM- 20160616
LR  - 20181202
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 29
IP  - 12
DP  - 2015 Jun
TI  - [Efficacy of sublingual immunotherapy with Dermatophagoides farina drops in 
      monosensitized and polysensitized patients with allergic rhinitis].
PG  - 1094-7
AB  - OBJECTIVE: To evaluate the efficacy of sublingual immunotherapy (SLIT) with 
      standardized Dermatophagoides farina drops in monosensitized and polysensitized 
      patients with allergic rhinitis. METHOD: The clinical data of 162 patients 
      treated with standardized Dermatophagoides farina drops were analyzed 
      retrospectively. These patients were divided into the monoallergen sensitized 
      group and polyallergen sensitized group according to the results of skin prick 
      tests. The total nasal symptoms score (TNSS), the total medication score (TMS) 
      and adverse effects (AEs) were evaluated before treatment, 2 year after SLIT 
      treatment and 3 year after drug discontinuance. Result:After SLIT treatment for 2 
      years and drug discontinuance for 3 years, the TNSS (3. 14[2. 47; 3. 65], 3. 45 
      [2. 76; 3. 92], respectively) and TMS (0. 42[0. 36; 0. 57],0. 35[0. 26; 0. 44], 
      respectively) in the monoallergen sensitized group were lower than that before 
      the treatment (TNSS: 9. 00 [8. 00; 10. 00], TMS: 2. 16 [1. 88; 2. 37]), which 
      have showed a statistically significant difference(P<0. 05). Similarly, after 
      SLIT treatment for 2 years and drug discontinuance for 3 years, the TNSS (3. 
      14[2. 46; 3. 63], 4. 23[3. 65; 4. 96], respectively) and TMS (0. 42[0. 36; 0. 
      58], 0. 50[0. 34; 0. 72], respectively) in the polyallergen sensitized group were 
      lower than that before the treatment (TNSS: 9. 00[8. 00; 10. 00], TMS: 2. 18[1. 
      95; 2. 37]), which have showed a statistically significant difference(P<0. 05). 
      No statistically significant finding could be observed in monoallergen and 
      polyallergen sensitized group before the treatment and 2 years after treatment, 
      respectively. However, a statistically significant finding could be observed 
      between two groups in the drug discontinuance for 3 years (P<0. 05). Eleven 
      patients suffered local adverse effects, and the incidence of adverse effects 
      showed no significantly difference (P>0. 05). CONCLUSION: SLIT with standardized 
      Dermatophagoides farina drops has a long-term efficacy in monosensitized and 
      polysensitized patients with allergic rhinitis. Moreover, a longer SLIT treatment 
      (>2 years) may be necessary to consolidate its efficacy.
FAU - Cui, Long
AU  - Cui L
FAU - Xia, Zhongfang
AU  - Xia Z
FAU - Wang, Zhinan
AU  - Wang Z
FAU - Xu, Zhongqiang
AU  - Xu Z
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Antigens, Dermatophagoides)
SB  - IM
MH  - Administration, Sublingual
MH  - Animals
MH  - Antigens, Dermatophagoides/*therapeutic use
MH  - Humans
MH  - Pyroglyphidae
MH  - Retrospective Studies
MH  - Rhinitis, Allergic/*therapy
MH  - Skin Tests
MH  - *Sublingual Immunotherapy
MH  - Treatment Outcome
EDAT- 2015/10/31 06:00
MHDA- 2016/06/17 06:00
CRDT- 2015/10/31 06:00
PHST- 2015/10/31 06:00 [entrez]
PHST- 2015/10/31 06:00 [pubmed]
PHST- 2016/06/17 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1094-7.